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Creative Biolabs
Product

NeuroMab™ Anti-PCSK9 BBB Shuttle Antibody, Clone 8F5

[CAT#: NRZP-1022-ZP3010]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; Block; Inhib; In Vitro

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

8F5

Applications

ELISA; Block; Inhib; In Vitro
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

Amyloid Beta 1-42

Official Name

Amyloid Beta 1-42

Full Name

Amyloid beta

Alternative Names

APP; Aβ; Abeta; Amyloid β
Product Pictures
ELISA

Figure 1 is a graph showing the detection results of the binding ability of the 8F5 antibody to the human PCSK9 antibody;

ELISA

Figure 2 is a graph showing the detection results of the binding ability of antibody 8F5 to monkey PCSK9 antibody;

ELISA

Figure 3 is a graph showing the detection results of the binding ability of antibody 8F5 to mouse PCSK9 antibody;

ELISA

Figure 4 is a graph showing the competitive detection results of antibody 8F5 blocking the binding of human PCSK9 and LDLR;

ELISA

Figure 5 is a graph showing the experimental results of antibody 8F5 preventing LDLR down-regulation on HepG2 cells;

ELISA

Figure 6 is a comparison result graph of the effect of the 8F5 antibody and the original drug of the prior art on the LDL-C concentration in the body.

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For Research Use Only. Not For Clinical Use.
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