Product
NeuroMab™ Anti-IGF1R BBB Shuttle Antibody, Clone 8
[CAT#: NRZP-1022-ZP2839]
- Host Species:
- Human
- Species Reactivity:
- Human; Cynomolgus Monkey; Marmoset Monkey
- Applications:
- ELISA; FC; Inhib; In Vivo; In Vitro
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human; Cynomolgus Monkey; Marmoset Monkey
Clonality
Monoclonal
Host Species
Human
Clone Number
8
Applications
ELISA; FC; Inhib; In Vivo; In Vitro
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
IGF1R
Official Name
IGF1R
Full Name
insulin-like growth factor 1 (IGF-1) receptor
Alternative Names
IGF1R; CD221; IGFIR; IGFR; JTK13; insulin like growth factor 1 receptor; Insulin-like growth factor 1;IGF-1R
Product Pictures
FuncS
Figure 1 Primary tumor volume measured during treatment up to day 55.
Vehicle: 1; antibody 1A 20 mg/kg: 2; antibody 1A 7 mg/kg: 3; antibody 1A 2 mg/kg
Inhib
Figure 2 Inhibition of I125-IGF-I binding to HT29 cells by antibodies 1A, 8 and 23.
Inhib
Figure 3 The inhibitory effect of antibodies on the binding of I125-IGF-II to HT29 cells.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
