Product
NeuroMab™ Anti-IGF1R BBB Shuttle Antibody, Clone NR207P
[CAT#: NRZP-1022-ZP3402]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; IHC; Inhib; Block; In Vitro; In Vivo
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Immunogen
Human IGF-1R extracellular domain (1-906) -C3-muFc
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG
Clone Number
NR207P
Applications
WB; ELISA; IHC; Inhib; Block; In Vitro; In Vivo
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
IGF1R
Official Name
IGF1R
Full Name
insulin-like growth factor 1 (IGF-1) receptor
Alternative Names
IGF1R; CD221; IGFIR; IGFR; JTK13; insulin like growth factor 1 receptor; Insulin-like growth factor 1;IGF-1R
Product Pictures
ELISA
Figure 1 provides a graph illustrating that four phage-displayed antibodies bound significantly better to the IGF-IR-Fc molecule than they did to the insulin receptor-Fc or the murine Fc.
FuncS
Figure 2 provides a graph illustrating the ability of certain antibodies to compete with IGF-1 and IGF-2 for binding to IGF-IR.
FuncS
Figure 3 provides graphs illustrating the ability of certain antibodies to inhibit the growth of 32D hu IGF-1R+IRS-1 cells.
FuncS
Figure 4 provides a graph illustrating the ability of certain antibodies to inhibit the growth of Balb/C 3T3 hu IGF-IR cells.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
