NeuroMab™ Anti-IGF1R BBB Shuttle Antibody (NRZP-1022-ZP2830)
- Host Species:
- Mouse
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- ELISA; In Vitro; In Vivo; Inhib
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 5 Sensorgrams of the association and dissociation phases of IgG1 humanized I-3466/hIGF-IR-ECD complexes in five different concentrations of hIGF-IR-ECD.
Figure 6 Effect of I-3466 antibody on IGF1-induced growth of MCF-7 in vitro.
Figure 1 Tumor volume of Co1o205 colon adenocarcinoma xenografts treated with vehicle, Ang2-h38c2, IGF1R antibody (2.12.1.fx), or MAC-2 (IP, 1x/wk).
Data are depicted as the mean and SE of n=10/group for days 0-28 (n=10 for all groups beyond day 28). *: P <0.05, IGF1R antibody (2.12.1.fx) 10 mg/kg vs. MAC-2 10 mg/kg.
Figure 2 Relative IGF1R expression levels in lysates prepared from resected and frozen tumors.
Figure 3 Co1o205 colon adenocarcinoma xenografts were treated with vehicle, Ang2-h38c2 (10 mg/kg), IGF1R antibody (2.12.1.fx) (10 mg/kg) or MAC-2 (1, 3 or 10 mg/kg). kilogram).
Figure 4 Co1o205 colon adenocarcinoma xenografts using vehicle, Ang2-h38c2 (10 mg/kg), IGF1R antibody (2.12.1.fx and 2.13.2) (10 mg/kg), MAC-2 (1,3 or 10 mg/kg) or Ang2-h38c2 (10 mg/kg) in combination with 2.12.2.fx or 2.13.2 (10 mg/kg). All data are described as mean and standard error of n=10/group.
Figure 5 Tumor volume of MDA-MB-435 melanoma after weekly treatment with vehicle or MAC-2 (IP, weekly).
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