Neuronal Activity Assay

As an expert in the field of neuroscience, Creative Biolabs has accumulated rich experience in neuronal activity assays after decades of accumulation. Our vision is to provide high-quality neuronal activity assay services to customers all over the world to help you achieve great success in neuroscience projects.

Applications of Neuronal Activity Assays

Neuronal activity is intimately connected to the development of neuronal circuits. In addition, neuronal activity plays a critical role in regulating the localization and trafficking of synaptic vesicles, neurotransmitter receptors, and scaffold proteins. Monitoring changes in neuronal activity under normal and disease conditions is crucial for gaining insight into the pathogenesis of neurological disorders. Furthermore, monitoring changes in neuronal activity is a critical strategy for understanding the activity of neurons. Importantly, neuronal activity assays also provide attractive tools for drug screening.

Fig.1 Microelectrode array for extracellular recording of cortical network activity. (Gramowski-Voss, 2015)

What Can We Do?

For a long time, exploring the working mechanism of neuronal networks and their relationship with various diseases has been the focus in the field of neuroscience. At Creative Biolabs, numerous live-cell assays for monitoring changes in neuronal activity are available.

• Microelectrode array (MEA) assay

At Creative Biolabs, our compelling MEA assay platform for neuroscience serves as a useful tool to understand the electrical activity of cultured neurons as well as networks that form in vitro models.

• Electrophysiological recordings

Currently, electrical recording from single neurons remains one of the most attractive strategies to quantify changes in neuronal activity. Monitoring current and voltage changes across membranes contributes to revealing characteristics of membrane potential and is ideal for detecting the immediate effects of drug treatments.

• Secreted neuronal activity reporter (SNAR) assay

SNAR is an essential tool to monitor changes in neuronal activity in living neurons. In addition, SNAR allows revealing the temporal dynamics of neuronal responses within the same neuronal population. SNARs have many advantages, including intra-assay reliability, ease of use, and quantitative properties, and as a result, SNARs are emerging as an ideal tool for large-scale drug screening.

Features of Our Services

• Highly specific

In our assay, neurons form a network and develop functional network activity over time. The spontaneous firing of neurons is captured from each electrode, providing temporally and spatially precise data.

• Wide detection range

Our device can efficiently capture and analyze the short-term calcium flux dynamics of thousands of cells.

• Chronic studies

Quantify longitudinal changes in different moving targets while cells are placed undisturbed in specific incubators. Our neuronal activity assay facilitates the long-term assay of synaptic activity to characterize neuronal cellular models under physiologically relevant conditions.

• Customized service

Our dedicated team provides solutions tailored to the unique needs of each scientist to facilitate your project.

Cell Models at Creative Biolabs

Additionally, we offer a variety of cell models to power your neuroscience research.

• Primary Neuronal Cell Culture Models
• Human iPSC Derived Neuronal Cell Culture Models
• Cell Line Models
• Transgenic Cell Line Models
• Organotypic Brain Slice Models

Creative Biolabs is an innovative biotechnology company with a strong reputation that has been at the forefront of neuroscience for decades. After decades of accumulation, Creative Biolabs has built an advanced platform and a professional team. We specialize in providing tailored neuronal activity assay services to your specific needs. If you are interested in our neuronal activity assay services, please feel free to contact us for more details.

Reference

1. Gramowski-Voss, A.; et al. Enhancement of cortical network activity in vitro and promotion of GABAergic neurogenesis by stimulation with an electromagnetic field with a 150 MHz carrier wave pulsed with an alternating 10 and 16 Hz modulation. Frontiers in neurology. 2015, 6: 158.