Immortalized Cell Line Modeling Services

Creative Biolabs boasts advanced technological platforms and exceptional research team dedicated to providing comprehensive cell line model solutions for neuroscience research. We understand the unique needs of each client, and through meticulously designed projects, we ensure the best research solutions tailored specifically for you.

Available Cell Line Models for Neuroscience Research

Advantages

In the field of neuroscience, cell lines, primary cells, and induced pluripotent stem cells (iPSCs) each have their own advantages and disadvantages. Here are some of the main advantages of cell line models over primary cells and iPSCs:

• Availability: Cell lines can usually be cultured and expanded continuously in the laboratory, while the acquisition and culture of primary cells often require extraction from living tissues, which is a more complicated and time-consuming process.
• Long-term survival and proliferation: Cell lines can be cultured for long periods in vitro while maintaining their proliferative ability, whereas primary cells and iPSCs may rapidly decline or differentiate during in vitroculture.
• Homogeneity: Cell lines are usually homogenous populations, which can simplify experimental design and interpretation of data. In contrast, primary and iPSC-derived cultures may contain mixed cell populations that can complicate analysis.
• Transfection and Genetic Manipulation: Cell lines are easier to manipulate for gene editing and transfection with plasmids, allowing for rapid generation of stable cell lines with specific genetic modifications. This capacity for manipulation is often more challenging in primary cells or iPSC-derived cells.
• Cost-effectiveness: Since cell lines are easy to culture and can be used repeatedly and do not require frequent extraction of new cells, their long-term use costs may be lower than repeatedly obtaining primary cells or difficult maintaining and culturing iPSCs.

Applications

• Disease modeling: Cell line models can be utilized to investigate the mechanisms underlying neurodegenerative diseases such as Alzheimer's and Parkinson's disease, aiding in the understanding of pathological processes and identifying potential biomarkers.
• Drug screening and development: Cell line models are employed for preliminary screening of the efficacy and toxicity of potential drugs, including the development.
• Gene function studies: Utilizing transgenic or gene editing technologies, researchers can study the functions of specific genes in neuronal cells and their roles in disease contexts.
• Neurodevelopmental research: Cell line models can be used to observe the development of neurons, including critical events such as neurogenesis and synaptogenesis.

Contact Us Today

If you're looking to develop or inquire about cell line models for your research needs, feel free to reach out! We eagerly look forward to collaborating with you to advance the progress of science together.

Reference

1. Ding, Zhe et al. "Emerging Roles of Microglia in Neuro-vascular Unit: Implications of Microglia-Neurons Interactions." Front Cell Neurosci. 2021;15:706025. Distributed under Open Access license CC BY 4.0 without modification.