Cell Line Model Development Services

Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs has developed a series of cell line models for neuroscience research. We can meet the specific need of each customer with the best project design.

Introduction of Cell Line Models

The human brain is a complex organ composed of a variety of cell types and signaling pathways. Since mature neurons do not undergo cell division again, it is necessary to establish immortalized secondary cell lines derived from neuronal tumors, that is, to acquire the ability to generate in vitro cultures of neuronal cells. The established molecular tools and stem cell line models can mimic the physiology of the brain for a better understanding of neurological diseases and treatment strategies. Based on our excellent primary cells, stem cells, and other cell line models, it would be possible to create in vitro culture systems that mimic in vivo environments.

Cell Line Models for Neuroscience Research

Characterized by the functional deterioration of neurons, neurodegenerative diseases present severe implications for individuals and society. Creative Biolabs has developed several culture systems to study the pathogenesis of neurodegenerative diseases. For example, the human neuroblastoma cell line SH-SY5Y has been widely used for the research of Parkinson's disease (PD); the Lund human mesencephalic (LUHMES) immortalized cell line can be used for neurotoxicity studies. Our diverse cell models allow better characterization of disease markers and in vivo physiological conditions. In addition, our model also improves the understanding of human neurodegenerative diseases and can better characterize pathological mechanisms.

It is worth noting that 3D cultures, organotypic cultures, as well as organoids can be served as a complement to cell line models to further improve the precision and confidence of research.

Fig.1 Schematic representation of microfluidic brain model. (Slanzi, 2020)

Available Cell Line Models for Neuroscience Research

• Blood-Brain Barrier hCMEC/D3 Cell Line
• ReNcell CX Human Neural Progenitor Cell Line
• ReNcell VM Human Neural Progenitor Cell Line
• GT1-7 Mouse Hypothalamic GnRH Neuronal Cell Line
• O9-1 Mouse Cranial Neural Crest Cell Line
• Cryopreserved Mouse Cortical Neural Stem Cells
• Cryopreserved Mouse Spinal Cord Neural Stem Cells
• N27 Rat Dopaminergic Neural Cell Line
• Adult Rat Hippocampal Neural Stem Cells
• Rat Neuroblastoma Cells

To explore our extensive list of cell line resources, please click Neuros Cell Line Product Panel.

As a global company with extensive scientific expertise, we guide clients from discovery to approval and provide continuity for their entire program. If you are interested in our products and services, please do not hesitate to contact us for more details.

Reference

1. Slanzi, A.; et al. In vitro models of neurodegenerative diseases. Frontiers in cell and developmental biology. 2020, 8: 328.