NeuroMab™ Anti-LAG3 Antibody,Clone NR1223P
Functional antibody against Human LAG3
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; Inhib; In Vitro
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Species Reactivity
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Endotoxin Level
Low Endotoxin < 1 EU/mg
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Research Use Only
Figure 1 ELISA results showing EC50 of antibody binding to LAG3 intact extracellular domain (D1-D4 huFc) but not D1-D2 deleted LAG3 (△D1-D2 huFc).
Figure 2 Dose-dependent inhibition of the binding of LAG3 to its receptor MHC class II molecules.
Figure 3 122H, 147H, and 170H mouse mAbs dose-dependently promote IL2 production by Jurkat T cells.
Figure 4 Humanized monoclonal antibody 147H-13 dose-dependently promotes the production of IL2 by Jurkat T cells.
Figure 5 Effect of affinity matured anti-LAG3 antibody on stimulation of IL2 release from Jurkat T cells.
Figure 6 Anti-LAG3 antibody blocks the binding of Galectin-3 or LSECtin to LAG3.
Figure 7 The combination of anti-LAG3 antibody and anti-PD-L1 antibody produced significantly more IL-2 than each alone.
Figure 8 Combination of anti-PD-L1 antibody and 147H-13 shows strong inhibition of MC38 tumor growth.
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