NeuroMab™ Anti-Cavβ3 calcium channel BBB Shuttle Antibody, Clone N473/36
[CAT#: NRZP-0423-ZP68]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNB3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 20-149 (N-terminus) of human Cavbeta3 (also known as Voltagedependent L-type calcium channel subunit beta-3, Calcium channel voltage-dependent subunit beta 3, CAB3, CACNB3, CACNLB3 and CCHB3, accession number P54284)
Rat: 100% identity (130/130 amino acids identical)
Mouse: 99% identity (129/130 amino acids identical)
<70% identity with Cavbeta4 and other calcium channel subunits
Rat: 100% identity (130/130 amino acids identical)
Mouse: 99% identity (129/130 amino acids identical)
<70% identity with Cavbeta4 and other calcium channel subunits
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N473/36
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Cavbeta1, Cavbeta2 or Cavbeta4
Research Areas
Ca2+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
CACNB3
Official Name
CACNB3
Full Name
Cavbeta3 Ca2+ channel
Alternative Names
CACNB3; CAB3; CACNLB3; calcium voltage-gated channel auxiliary subunit beta 3
Uniprot ID
P54284
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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