NeuroMab™ Anti-Cavβ3 calcium channel BBB Shuttle Antibody, Clone N473/36

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNB3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 20-149 (N-terminus) of human Cavbeta3 (also known as Voltagedependent L-type calcium channel subunit beta-3, Calcium channel voltage-dependent subunit beta 3, CAB3, CACNB3, CACNLB3 and CCHB3, accession number P54284)
Rat: 100% identity (130/130 amino acids identical)
Mouse: 99% identity (129/130 amino acids identical)
<70% identity with Cavbeta4 and other calcium channel subunits

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N473/36

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Cavbeta1, Cavbeta2 or Cavbeta4

Research Areas

Ca2+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CACNB3

Official Name

CACNB3

Full Name

Cavbeta3 Ca2+ channel

Alternative Names

CACNB3; CAB3; CACNLB3; calcium voltage-gated channel auxiliary subunit beta 3

Uniprot ID

P54284

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with MycFlag-tagged Cavbeta1, Cavbeta2, Cavbeta3, Cavbeta4 or untagged Kv2.1 plasmid probed with N473/86 (left) or mouse anti-Flag (right).