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Creative Biolabs

Acute Spinal Cord Injury Related Antibodies

Spinal cord injury (SCI) can be divided into primary and secondary injuries based on the mechanism of injury. The former is caused by the initial external force acting directly or indirectly on the spinal cord, while the latter is based on a series of physiological and biochemical mechanisms, such as oxidative stress, inflammatory response and excessive release of excitatory amino acids, which cause the intact tissue around the lesion to undergo self-destructive lesions, further deepening the degree of injury and expanding the area of injury.

Key Factors Related Products

Key Factors of SCI

  • Inflammasome
    The inflammatory response is the major pathological process in the secondary injury phase. In the acute phase, reducing secondary injury by inhibiting neuroinflammation is believed to reduce damage to nerve function and achieve neuroprotection. A class of protein complexes known as inflammasome is primarily scaffolded by pattern recognition receptors from the PHYIN and NLR families as well as other receptor proteins. Some examples of common inflammasomes are AIM2, NLRP1, NLRP3, and NLRC4 (IPAF).
NLRP3 NLRC4 AIM2
Cat. No Product Name Host Application
NAB2105337SL Mouse Anti-Human NLRP3 Monoclonal Antibody (CBP5787) Mouse IF; IHC; IP; WB
NRZP-0922-ZP3526 NeuroMab™ Anti-NLRP3 Antibody, Clone N25445 (CBP14837) Rabbit WB; IP
NRZP-0922-ZP3527 NeuroMab™ Anti-NLRP3 Antibody, Clone N13357 (CBP14838) Rabbit WB; IP
NRZP-0323-ZP119 NLRP3 Inflammasome Antibody Panel

See all NLRP3 antibodies

Cat. No Product Name Host Application
NRZP-0922-ZP3525 NeuroMab™ Anti-NLRC4 Antibody, Clone N16098 (CBP14836) Rabbit WB; IP

See all NLRC4 antibodies

Cat. No Product Name Host Application
NRZP-0922-ZP1490 NeuroMab™ Anti-AIM2 Antibody, Clone N15125 (CBP12801) Rabbit WB; IP
NRZP-0922-ZP1491 NeuroMab™ Anti-AIM2 Antibody, Clone N17161 (CBP12802) Rabbit WB; IP

See all AIM2 antibodies

    Immune Response
    Immune response is a key pathological mechanism of SCI and determines the prognosis of the disease. When SCI occurs, local microglial reactions and the breakdown of the blood-spinal barrier allow blood-borne immune cells to enter the spinal cord. These cells release proinflammatory or immunomodulatory substances and contribute to the immune response. The immune response has always been thought to be harmful and detrimental to the repair of SCI. In the pathophysiology of SCI, all brain functioning cells exhibit pathogenic reactions, and neural cells and inflammatory cells communicate improperly. Understanding the pathogenic mechanism of SCI and identifying important regulatory targets will be aided by analyzing the response and communication mechanisms of these essential functional cells.

Fig 1 A schematic illustration of cellular changes post SCI. (Hu, et al., 2023) Fig.1 Schematic illustrating cellular changes following SCI1.

At Creative Biolabs, our objective is to assist our clients in acquiring the most recent antibodies required for SCI research. Should you require further information regarding SCI-related antibodies, we invite you to explore the related products below or to contact us directly. We will respond to your inquiry in a timely manner.

Reference

  1. Hu, Xiao, et al. "Spinal cord injury: molecular mechanisms and therapeutic interventions." Signal transduction and targeted therapy 8.1 (2023): 245.
For Research Use Only. Not For Clinical Use.

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