Acute Spinal Cord Injury Related Antibodies
Spinal cord injury (SCI) can be divided into primary and secondary injuries based on the mechanism of injury. The former is caused by the initial external force acting directly or indirectly on the spinal cord, while the latter is based on a series of physiological and biochemical mechanisms, such as oxidative stress, inflammatory response and excessive release of excitatory amino acids, which cause the intact tissue around the lesion to undergo self-destructive lesions, further deepening the degree of injury and expanding the area of injury.
Key Factors of SCI
-
Inflammasome
The inflammatory response is the major pathological process in the secondary injury phase. In the acute phase, reducing secondary injury by inhibiting neuroinflammation is believed to reduce damage to nerve function and achieve neuroprotection. A class of protein complexes known as inflammasome is primarily scaffolded by pattern recognition receptors from the PHYIN and NLR families as well as other receptor proteins. Some examples of common inflammasomes are AIM2, NLRP1, NLRP3, and NLRC4 (IPAF).
Cat. No | Product Name | Host | Application |
---|---|---|---|
NAB2105337SL | Mouse Anti-Human NLRP3 Monoclonal Antibody (CBP5787) | Mouse | IF; IHC; IP; WB |
NRZP-0922-ZP3526 | NeuroMab™ Anti-NLRP3 Antibody, Clone N25445 (CBP14837) | Rabbit | WB; IP |
NRZP-0922-ZP3527 | NeuroMab™ Anti-NLRP3 Antibody, Clone N13357 (CBP14838) | Rabbit | WB; IP |
NRZP-0323-ZP119 | NLRP3 Inflammasome Antibody Panel |
Cat. No | Product Name | Host | Application |
---|---|---|---|
NRZP-0922-ZP3525 | NeuroMab™ Anti-NLRC4 Antibody, Clone N16098 (CBP14836) | Rabbit | WB; IP |
Cat. No | Product Name | Host | Application |
---|---|---|---|
NRZP-0922-ZP1490 | NeuroMab™ Anti-AIM2 Antibody, Clone N15125 (CBP12801) | Rabbit | WB; IP |
NRZP-0922-ZP1491 | NeuroMab™ Anti-AIM2 Antibody, Clone N17161 (CBP12802) | Rabbit | WB; IP |
-
Immune Response
Immune response is a key pathological mechanism of SCI and determines the prognosis of the disease. When SCI occurs, local microglial reactions and the breakdown of the blood-spinal barrier allow blood-borne immune cells to enter the spinal cord. These cells release proinflammatory or immunomodulatory substances and contribute to the immune response. The immune response has always been thought to be harmful and detrimental to the repair of SCI. In the pathophysiology of SCI, all brain functioning cells exhibit pathogenic reactions, and neural cells and inflammatory cells communicate improperly. Understanding the pathogenic mechanism of SCI and identifying important regulatory targets will be aided by analyzing the response and communication mechanisms of these essential functional cells.
Fig.1 Schematic illustrating cellular changes following SCI1.
At Creative Biolabs, our objective is to assist our clients in acquiring the most recent antibodies required for SCI research. Should you require further information regarding SCI-related antibodies, we invite you to explore the related products below or to contact us directly. We will respond to your inquiry in a timely manner.
Reference
- Hu, Xiao, et al. "Spinal cord injury: molecular mechanisms and therapeutic interventions." Signal transduction and targeted therapy 8.1 (2023): 245.
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P515) (Cat#: NRP-0422-P515)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2293) (Cat#: NRP-0422-P2293)
- NeuroMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P517) (Cat#: NRP-0422-P517)
- NeuroMab™ Anti-GD2 Antibody(NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1683) (Cat#: NRP-0422-P1683)
- NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P614) (Cat#: NRP-0422-P614)
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- NeuroMab™ Anti-CD20 Antibody(NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Human CMEC/D3 Cell Line, Blood-Brain Barrier Model (Cat#: NCL-2108-P020)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Green Fluorescent Tau SH-SY5Y cell Line (Cat#: NCL2110P219)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA (Cat#: NTA-2012-ZP78)
- PRV-CAG-EGFP (Cat#: NTA-2011-ZP14)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)