Multiple Sclerosis Related Antibodies

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS). The spatial and temporal multiplicity of lesions are the prominent features of this disease. Most MS patients begin with relapsing-remitting MS (RRMS), which develops into secondary progressive MS (SPMS) with increased clinical exacerbations. MS may be caused by genetic susceptibility, environment, lifestyle, viral infection and immune mechanisms. The above causes urgently need further research and large sample randomized controlled clinical trials to verify. Clarifying the cause and pathogenesis of MS will be the focus of future research.

Key Factors of MS

• Myelin sheath: The immune system mistakenly attacks the myelin sheath, a protective covering of nerve fibers in the central nervous system. Targeting this process can help prevent further damage to nerve cells. These include MBP, myelin-associated glycoprotein (MAG), MOG, PLP, CRYAB, and oligodendrocyte-specific protein.

• Immune cells: MS' immunological response is mediated by specific immune cell types. Targeting these immune cells can help regulate the immune system and protect nerve cells. These cells include T cells, B cells, microglia, macrophages, and dendritic cells.

See all Iba1 antibodies

• Neuroinflammation: Neuroinflammation is a significant factor in the progression of MS. Targeting inflammatory pathways can help alleviate symptoms and avoid relapses. These include pro- and anti-inflammatory cytokines secreted by microglia, macrophages and dendritic cells.

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