Immortalized Cell Lines
Cell immortalization refers to the process in which cells cultured in vitro break free from the limits of cellular spontaneous senescence, acquire the ability to proliferate indefinitely under the influence of external factors. Cells derived from normal tissues can divide and grow under typical in vitro culture conditions, but after a limited number of passages, they stop proliferating, undergo aging, and eventually die. By introducing exogenous immortalizing genes into target cells through techniques such as gene transfection, immortalized cell lines can be established to make cultured cells proliferative and homogeneous. In-depth research on cell immortalization is not only beneficial for understanding the molecular mechanisms of cell proliferation and aging but also lays a solid foundation for exploring cancer therapy and organ transplantation research. Additionally, immortalized cells can be passaged multiple times, providing researchers with a valuable resource for various cell models and facilitating scientific research.
In addition to providing a comprehensive range of widely used immortalized cell lines, Creative Biolabs has many years of experience in cell immortalization services and has successfully established a variety of immortalized cell lines, including those sourced from humans, mice, rats, and rabbits.
Cell Immortalization Methods
Mammalian cells can be immortalized using several methods. Among them, induction of cell immortalization by SV40 T antigen and hTERT virus is the simplest and most reliable, widely used.
Advantages
With Creative Biolabs, you can effortlessly obtain excellent immortalized cell products.
Well-identified
STR identification
Species identification
Immunofluorescence identification
High Quality
Passages number ≤5
Cell viability >90%
Cell number ≥1×106 cells/vial
Trending Products
Creative Biolabs is dedicated to providing reliable immortalized cell lines to speed up your neuroscience research.
| Cat. No. | Product Name | Cat. No. | Product Name |
| NCL-2105-P182-AM | Human Astrocytes, Immortalized | NCL2110P001 | Mouse Hippocampal Neuron Cell HT22 |
| NCL-21P6-221 | Rat Cerebellar Granule Cell Line, Immortalized | NCL2110P059 | Mouse Midbrain Dopaminergic Neuron Cell MN9D |
| NCL2110P073 | Mouse Microglia N9, Immortalized | NCL2110P206 | Immortalized Human Microglia |
| NCL2110P153 | Mouse Microglia Cell Line BV-2, Immortalized | NCL-2108P38 | Human Microglia Cell Line HMC3, Immortalized |
| NCL-2108P34 | Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) | NCL2110P015 | Rat Microglia Cell Line HAPI, Immortalized |
| NCL-2108-P020 | Human CMEC/D3 Cell Line, Blood-Brain Barrier Model | NCB2108FY0001 | Mouse bEnd.3 [BEND3] Cells |
| NCL2110P098 | Mouse Dendritic Cell DC2.4 | NCL-2108P21 | Rat Schwann Cells RSC96, Immortalized |
| NCL-21P6-192 | Rat Retinal Muller Cell Line, Immortalized | NCL-2106-S93 | Rat Immortalized Retinal Muller Cell Line rMC-1 |
| NCL-21P6-177 | Immortalized Human Alveolar Epithelial Cell Line | NCL-21P6-176 | Mouse Kupffer Cell Line (ImKC), Immortalized |
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Mouse Retinal Ganglion Cell Line RGC-5 [CAT#: NCL2110P154]
- Species:
- Mouse
- Applications:
- Cell Culture
- Cell Types:
- Visual system-related Cells
Mouse Microglia Cell Line BV-2, Immortalized [CAT#: NCL2110P153]
- Species:
- Mouse
- Applications:
- Cell Culture
- Cell Types:
- Microglia
Mouse Microglia N9 [CAT#: NCL2110P073]
- Species:
- Mouse
- Applications:
- Cell Culture
- Cell Types:
- Microglia
Human Retinal Epithelial Cell ARPE-19 [CAT#: NCL2110P069]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Visual system-related Cells
Mouse Midbrain Dopaminergic Neuron Cell MN9D [CAT#: NCL2110P059]
- Species:
- Mouse
- Applications:
- Cell Culture
- Cell Types:
- Neurons
Rat Microglia Cell Line HAPI, Immortalized [CAT#: NCL2110P015]
- Species:
- Rat
- Applications:
- Cell Culture
- Cell Types:
- Microglia
Mouse Hippocampal Neuron Cell HT22 [CAT#: NCL2110P001]
- Species:
- Mouse
- Applications:
- Cell Culture
- Cell Types:
- Neurons
Human CMEC/D3 Cell Line, Blood-Brain Barrier Model [CAT#: NCL-2108-P020]
The hCMEC/D3 BBB cell line has been extensively characterized for brain endothelial phenotype and is a model of human blood-brain barrier (BBB) function.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- BBB-related Cells
Human Microglia Cell Line HMC3, Immortalized [CAT#: NCL-2108P38]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Microglia
Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) [CAT#: NCL-2108P34]
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Tumor Cells
Rat Schwann Cells RSC96, Immortalized [CAT#: NCL-2108P21]
- Species:
- Rat
- Applications:
- Cell Culture
- Cell Types:
- Schwann Cells
Rat Retinal Muller Cell Line, Immortalized [CAT#: NCL-21P6-192]
Immortalized Cell Lines
- Species:
- Rat
- Applications:
- Cell Culture
- Cell Types:
- Visual system-related Cells
Rat Immortalized Retinal Muller Cell Line rMC-1 [CAT#: NCL-2106-S93]
Constitutively express GFAP and CRALBP.
- Species:
- Rat
- Cell Types:
- Visual system-related Cells
Human Astrocytes, Immortalized [CAT#: NCL-2105-P182-AM]
Positive for GFAP
- Species:
- Human
- Cell Types:
- Astrocytes
- Species:
- Human
- Cell Types:
- Tumor Cells
- Species:
- Human
- Cell Types:
- Visual system-related Cells
- Species:
- Human
- Cell Types:
- BBB-related Cells
- Species:
- Human
- Cell Types:
- BBB-related Cells
- Species:
- Human
- Cell Types:
- BBB-related Cells
- Species:
- Human
- Cell Types:
- BBB-related Cells
Fluorescent Immortalized Primary Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Microglia
Fluorescent Immortalized Primary Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Microglia
Fluorescent Immortalized Primary Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- BBB-related Cells
Fluorescent Immortalized Primary Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- BBB-related Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Visual system-related Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Microglia
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Visual system-related Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Visual system-related Cells
The SV40-tranduced immortalized cells can go beyond 30 passages.
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Visual system-related Cells
- Species:
- Human
- Applications:
- Cell Culture
- Cell Types:
- Schwann Cells
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- NeuroMab™ Anti-EPHB2 Antibody(NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1684) (Cat#: NRP-0422-P1684)
- NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P614) (Cat#: NRP-0422-P614)
- NeuroMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody(NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- NeuroMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- NeuroMab™ Anti-CD32b Antibody(NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- iNeu™ Human Midbrain Dopaminergic Neurons (Cat#: NCL-21P6-003)
- Human Hippocampal Neuron Cells HPPNCs (Cat#: NCL2110P106)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Sf295 Human Glioblastoma Cells (Cat#: NCL-2108P180)
- Green Fluorescent Alpha-synuclein SH-SY5Y Cell Line (Cat#: NCL2110P209)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- iNeu™ Microglia (Cat#: NCL-7P018)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- pAAV-syn-jGCaMP8s-WPRE (Cat#: NTA-2106-P063)
- PRV-CAG-EGFP (Cat#: NTA-2011-ZP14)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
