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Creative Biolabs

Alzheimer's Disease Related Antibodies

Alzheimer's disease (AD), the most common type of dementia, is projected to triple in prevalence by 2050, posing a major worldwide health concern with significant implications for individuals and society. The initial symptoms of AD are insidious, progressive problems centered on episodic memory. The criteria for amnestic-moderate cognitive impairment (MCI) may be met at this point. Memory challenges, loss of confidence, and difficulties multitasking follow. Cognitive impairments become severe and pervasive as the condition progresses, even interfering with regular life tasks. At this time, patients can be diagnosed with Alzheimer's disease dementia.

Key Factors Important Targets Related Products

Key Factors of AD

The key pathology characteristic features of AD are amyloid plaques and neurofibrillary tangles (NFT). Additionally, there are also neuronal threads, neuroinflammation, dystrophic neurites, astrogliosis, and microglial activation. Amyloid plaques in the brain Vascular disorders usually coexist. Neurodegeneration, synaptic and neuronal loss, and macroscopic atrophy are all downstream effects of these pathogenic processes. Genes related to AD are shown in Figure 1. In addition to , Tau, PSEN, APOE, TREM2, and TDP-43 are all popular antibody targets in Alzheimer's disease research.

Fig 1 Genes associated with AD. (Lane, et al., 2018) Fig.1 An overview of genes that have been implicated in Alzheimer's disease.1

Important Targets Related to AD

Creative Biolabs supplies an array of antibodies for AD research to assist scientists with clarifying the etiology of the disease and slowing its progression. Antibodies are a workhorse technique in neuroscience research, with applications including Western blotting, immunofluorescence, ELISA, flow cytometry, and immunoprecipitation.

BACE1 GSK-3 SORL1 ABCA7 GCH1
Cat. No Product Name Host Application
NRP-0422-P996 Anti-BACE1 Antibody, Clone 1A11 Mouse WB; ELISA; In Vitro; Inhib
NRP-0422-P997 Anti-BACE1 Antibody, Clone 5G7 Mouse WB; ELISA; In Vitro; Inhib
NAB201269LS Anti-Human BACE1 Monoclonal Antibody (CBP3719) Mouse WB
NRZP-1022-ZP3374 Anti-BACE1 BBB Shuttle Antibody, Clone 1D7 Mouse WB; ELISA; FC; Inhib; Block; Cyt; In Vitro
NRZP-1022-ZP3678 Anti-BACE1 BBB Shuttle Antibody, Clone NR222P Mouse ELISA; In Vitro; In Vivo; Inhib

See all BACE1 antibodies

Cat. No Product Name Host Application
NRZP-0922-ZP2643 Anti-GSK-3β Antibody, Clone N412 (CBP13954) Rabbit WB; IP; IHC; IF; FC
NRZP-0922-ZP2647 Anti-GSK-3α Antibody, Clone N9726 (CBP13958) Rabbit WB; IP; IF
NRZP-0922-ZP2646 Anti-GSK-3α/β Antibody, Clone N32060 (CBP13957) Rabbit WB; IP
NRZP-0922-ZP2649 Anti-Phospho-GSK-3α (CBP13960) Rabbit WB; IP
NRZP-0922-ZP2650 Anti-Phospho-GSK-3α/β (CBP13961) Rabbit WB; IP
NRZP-0922-ZP2654 Anti-Phospho-GSK-3β (CBP13965) Rabbit WB; IP; IF; FC
NPP2011ZP71 Mouse GSK3 beta Antibody Pair, BSA and Azide Free [Colorimetric] Rabbit ELISA

See all GSK-3 antibodies

Cat. No Product Name Host Application
NAB-0720-Z6471 Rabbit Anti-SORL1 Monoclonal Antibody (CBP3355) Rabbit WB; IHC-P
NRZP-0522-ZP33 Anti-SORL1, Mouse Monoclonal Antibody, Clone 3B6B11 (CBP8686) Mouse ICC; IHC-P; WB
NRZP-0922-ZP4283 Anti-SORL1 Antibody, Clone N3801 (CBP15594) Rabbit WB; IF

See all SORL1 antibodies

Cat. No Product Name Host Application
NAB20101988CR Mouse Anti-ABCA7 Monoclonal Antibody (CBP2910) Mouse IHC; WB; ELISA
NRZP-0822-ZP928 Anti-ABCA7 Antibody, Clone N34990P (CBP9262) Rat WB; FC; IHC; IHC-P
NRZP-0922-ZP1427 Anti-ABCA7 Antibody, Clone N19706 (CBP12738) Rabbit WB; IP

See all ABCA7 antibodies

Cat. No Product Name Host Application
NAB-0720-Z2331 Anti-GCH1 Monoclonal Antibody (CBP610) Mouse WB; IHC-P

See all GCH1 antibodies

If you'd like to learn more about AD-related antibodies, please click on the related products below or contact us directly, and we'll get back to you as soon as possible.

Reference

  1. Lane, C A et al. “Alzheimer's disease.” European journal of neurology vol. 25,1 (2018): 59-70.
For Research Use Only. Not For Clinical Use.

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