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Creative Biolabs

RNAi Substrates

RNA interference (RNAi) is an intracellular gene expression regulation mechanism that can inhibit the expression of specific genes by specifically degrading mRNA. Since Andrew Fair and Craig Mello won the Nobel Prize in Physiology or Medicine in 2006 for their discovery of RNA interference, RNA interference technology has shown great potential for application in biomedical research, the development of therapeutic strategies, and the improvement of crop resistance.

Creative Biolabs offers a comprehensive range of innovative RNAi tools, siRNA products including siRNA, miRNA and lentiviral particles to support and accelerate your research in the neuroscience field.

Applications

The applications of RNA interference technology are extremely broad. It has been widely used in gene function research, disease modeling, and gene therapy.

Applications Description
Gene Function Research RNAi provides a rapid and effective means of targeting and silencing specific genes to study the function of specific genes and related pathways. Using siRNA knockdown or miRNA overexpression/knockout, researchers can analyze the biological function of genes in in vitro cell culture and in vivo animal models.
Gene Therapy RNAi is considered to be a revolutionary therapy, especially for targeting genes and pathways that are difficult to treat with traditional drugs. Currently, a number of RNAi treatment strategies for tumors, viral infections (such as HIV and hepatitis viruses), neurodegenerative diseases, and rare diseases are now being developed or tested in preclinical trials.
Agricultural Applications Another potential application of RNAi is in agriculture. In crop improvement, RNAi can improve the resistance of crops to insects, salt and alkali, and drought. By silencing specific genes, the use of pesticides can be reduced, thereby improving the quality of agricultural products while protecting the environment.

Our custom services provide ready-to-use constitutive or inducible overexpression lentiviruses for any specific gene, as well as high-titer, ready-to-use shRNA lentiviruses for your target. Please contact us to discuss your custom project or to inquire about our RNAi products.

For Research Use Only. Not For Clinical Use.

Target

Related Products
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For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.

Applications:
RNAi
Applications:
RNAi
Huntingtin Therapeutic siRNA [CAT#: NV-2106-P51]

Applications:
RNAi
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RNAi
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RNAi
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RNAi
CTNNB1 siRNA Oligonucleotide (D7) [CAT#: NV-2106-P46]

Applications:
RNAi
CTNNB1 siRNA Oligonucleotide (D6) [CAT#: NV-2106-P45]

Applications:
RNAi
CTNNB1 siRNA Oligonucleotide (D5) [CAT#: NV-2106-P44]

Applications:
RNAi
CTNNB1 siRNA Oligonucleotide (D4) [CAT#: NV-2106-P43]

Applications:
RNAi
CTNNB1 siRNA Oligonucleotide (D3) [CAT#: NV-2106-P42]

Applications:
RNAi
CTNNB1 siRNA Oligonucleotide (D2) [CAT#: NV-2106-P41]

Applications:
RNAi
Applications:
RNAi
CTNNB1 siRNA Oligonucleotide (D1) [CAT#: NV-2106-P39]

Applications:
RNAi
BCL2L1 siRNA [CAT#: NV-2106-P32]

This gene is available from: Human, Mouse, Rat

Applications:
RNAi
ATXN3 Antisense Oligonucleotide [CAT#: NV-2106-P31]

The antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Applications:
RNAi
ADAM17 siRNA [CAT#: NV-2106-P30]

The siRNA is designed for inhibiting ADAM17 (a disintegrin and metalloprotease 17) genes and used to inhibit the inflammation factor expression so as to realize the treatment for the arthritis.

Applications:
RNAi
Rat PPIB shRNA Plasmid [CAT#: NV-2106-P26]

Applications:
RNAi
Mouse PPIB shRNA Plasmid [CAT#: NV-2106-P25]

Applications:
RNAi
Human PPIB shRNA Plasmid [CAT#: NV-2106-P24]

Applications:
RNAi
Human PPIB siRNA [CAT#: NV-2106-P23]

Applications:
RNAi
Mouse PPIB siRNA [CAT#: NV-2106-P22]

Applications:
RNAi
Rat PPIB siRNA [CAT#: NV-2106-P21]

Applications:
RNAi
SOD1 siRNA [CAT#: NV-2106-P16]

For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.

Insert Size (bp):
piLenti-siRNA-GFP: 9043bp
pAAV-siRNA-GFP-hGH-amp: 6013bp
Applications:
RNAi

For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.

Applications:
RNAi

For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.

Applications:
RNAi
Rat SOD1 shRNA Silencing AAV [CAT#: NV-2106-P08]

Applications:
RNAi
Mouse SOD1 shRNA Silencing AAV [CAT#: NV-2106-P07]

Applications:
RNAi
Human SOD1 shRNA Silencing AAV [CAT#: NV-2106-P06]

Applications:
RNAi
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