RNAi Substrates
RNA interference (RNAi) is an intracellular gene expression regulation mechanism that can inhibit the expression of specific genes by specifically degrading mRNA. Since Andrew Fair and Craig Mello won the Nobel Prize in Physiology or Medicine in 2006 for their discovery of RNA interference, RNA interference technology has shown great potential for application in biomedical research, the development of therapeutic strategies, and the improvement of crop resistance.
Creative Biolabs offers a comprehensive range of innovative RNAi tools, siRNA products including siRNA, miRNA and lentiviral particles to support and accelerate your research in the neuroscience field.
Applications
The applications of RNA interference technology are extremely broad. It has been widely used in gene function research, disease modeling, and gene therapy.
| Applications | Description |
| Gene Function Research | RNAi provides a rapid and effective means of targeting and silencing specific genes to study the function of specific genes and related pathways. Using siRNA knockdown or miRNA overexpression/knockout, researchers can analyze the biological function of genes in in vitro cell culture and in vivo animal models. |
| Gene Therapy | RNAi is considered to be a revolutionary therapy, especially for targeting genes and pathways that are difficult to treat with traditional drugs. Currently, a number of RNAi treatment strategies for tumors, viral infections (such as HIV and hepatitis viruses), neurodegenerative diseases, and rare diseases are now being developed or tested in preclinical trials. |
| Agricultural Applications | Another potential application of RNAi is in agriculture. In crop improvement, RNAi can improve the resistance of crops to insects, salt and alkali, and drought. By silencing specific genes, the use of pesticides can be reduced, thereby improving the quality of agricultural products while protecting the environment. |
Our custom services provide ready-to-use constitutive or inducible overexpression lentiviruses for any specific gene, as well as high-titer, ready-to-use shRNA lentiviruses for your target. Please contact us to discuss your custom project or to inquire about our RNAi products.
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Mouse SOD1 shRNA Silencing Adenovirus [CAT#: NV-2106-P14]
For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
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- RNAi
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- RNAi
This gene is available from: Human, Mouse, Rat
- Applications:
- RNAi
The antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.
- Applications:
- RNAi
The siRNA is designed for inhibiting ADAM17 (a disintegrin and metalloprotease 17) genes and used to inhibit the inflammation factor expression so as to realize the treatment for the arthritis.
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.
- Insert Size (bp):
- piLenti-siRNA-GFP: 9043bp
pAAV-siRNA-GFP-hGH-amp: 6013bp
- Applications:
- RNAi
For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.
- Applications:
- RNAi
For each gene, lentivirus vector, adenovirus vector, AAV vector are avaliblle and can be made very quickly.
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- Applications:
- RNAi
- iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- iNeuMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody (NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Anti-ApoC3 BBB Shuttle Antibody (NRZP-1022-ZP3505) (Cat#: NRZP-1022-ZP3505)
- iNeuMab™ Anti-CD32b Antibody (NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- iNeuMab™ Anti-TREM2 Antibody (NRP-0422-P792) (Cat#: NRP-0422-P792)
- iNeuMab™ Anti-SEZ6 Antibody (NRP-0422-P515) (Cat#: NRP-0422-P515)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P2293) (Cat#: NRP-0422-P2293)
- iNeuMab™ Anti-Alpha Synuclein BBB Shuttle Antibody (NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Immortalized Human Cerebral Microvascular Endothelial Cells (Cat#: NCL-2108-P020)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
