Huntington's Disease Related Antibodies

Huntington's disease (HD), also known as "chorea", was originally reported by Waters in 1842 and termed after its systematic description by American physician George Huntington in 1872. HD is a progressive disease, and patients in the early stages of HD may suffer minor involuntary movements, mild executive function impairments, and sad mood. As the disease progresses, clinical symptoms of patients typically include involuntary convulsive movements, difficulties coordinating voluntary movements, mood swings, cognitive impairment, and other mental illnesses.

Key Factors of HD

HD is an autosomal dominant disorder caused by aberrant expansion (40 or more) of DNA repeats (composed of cytosine-adenine-guanine (CAG)) toward one end of the huntingtin protein (HTT). HTT is found throughout the central nervous system and has been linked to a number of cellular activities such as protein trafficking, vesicle transport, and selective autophagy. As the number of CAG repeats rises, HTT becomes more prone to misfolding and the production of insoluble aggregates. These aggregates build up and promote cell degeneration, eventually resulting in significant shrinkage of the affected brain areas.

The pathogenic hallmarks of HD are striatal atrophy and cerebral cortex cellular degeneration. The exact function of mutant huntingtin protein (mHTT) in the pathophysiology of HD is still unknown, but research has shown that it affects HD patients in a number of ways, including autophagy dysregulation, dopaminergic imbalance, oxidative stress and mitochondrial dysfunction, unusual protein aggregation, disruption of gene transcription, loss of nutritional support, and neuroinflammation.

Fig.1 Pathogenesis of Huntington's disease.¹

Important Targets Related to HD

Antibodies, as a dependable tool, are significant in HD research. Creative Biolabs has professional neuroscience and antibody R&D teams that can provide thorough and professional antibody suggestions for your HD research.

You may contact us directly or use the related products below to request additional information, and we will respond as soon as we can.

Reference

1. Jiang, Andrew, et al. "From pathogenesis to therapeutics: a review of 150 years of Huntington’s disease research." International journal of molecular sciences 24.16 (2023): 13021. Distributed under Open Access license CC BY 4.0, without modification.