iPSC and iPSC-derived Cells
Induced pluripotent stem cells (iPSCs) are a type of stem cells that are generated from embryonic cells or adult somatic cells, such as mesenchymal stromal cells (MSCs), fibroblasts and peripheral blood mononuclear cells (PBMCs) through a process called reprogramming. This reprogramming involves introducing OCT4, SOX2, KLF4, and L-MYC genes by episomal plasmids or retroviral transduction that are essential for maintaining pluripotency. iPSCs have the remarkable ability to self-renew and develop into any type of somatic cell, making them valuable and powerful tools for disease modeling and drug discovery.
With a decade of expertise in the field, Creative Biolabs has built up advanced manufacturing capabilities for producing top-notch, functional iPSC and iPSC-derived cells with exceptional uniformity. If you are looking for iPSC-related cells, please feel free to contact us. We also provide made-to-order products with our lines or your lines.
Case Study
Microglia are immune cells found in the brain that help maintain the health and function of neural cells. Dysfunction in microglia has been linked to the development of neurodegenerative diseases, like Alzheimer's disease, where they may contribute to the progression of symptoms and cognitive decline.
We have optimized a culture protocol to generate single microglia from iPSCs, which specifically express Iba1, P2Y12, and TREM2, for modeling neurodegenerative and neuroinflammatory diseases.
Fig.1 Human iPSC-derived microglia stain positive for Iba1 (cyan), P2Y12 (yellow), and TREM2 (red).1
Trending Products
We are proud to offer a catalog of ready-to-ship iPSC and iPSC-derived cells from healthy or diseased patients (Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis) to help explore the research of neuroscience, pain, and sensation.
| Cat. No. | Product Name | Cat. No. | Product Name |
| NCL-2103-P85 | Human iPSC Line (Episomal, PBMC-derived) | NCL-2105-P121-IX | Human iPS Cell Line (Alzheimer's Disease) |
| NCL-2105-P127-IX | Human iPS Cell Line (Parkinson's Disease) | NCL-2105-P126-IX | Human iPS Cell Line (Amyotrophic Lateral Sclerosis) |
| NCL-2105-P128-IX | Human iPS Cell Line (SOD1 mutation, A4V, HOM) | NCL200552ZP | iNeu™ Human Neural Stem Cell Line |
| NCL-2101-ZP09 | iNeu™ Human Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E) | NCL-2103-P80 | iNeu™ Human Neural Progenitor Cells |
| NCL-7P030 | iNeu™ Astrocytes | NCL-7P018 | iNeu™ Microglia |
| NCL-7P031 | iNeu™ Microglia AD APOE E4/E4 | NCL-2103-P78 | iNeu™ Human Cortical Neurons |
| NRZP-1122-ZP263 | iNeu™ Human Striatal Neurons | NRP-0322-P2180 | iNeu™ Human Peripheral Neurons |
| NCL-2105-P132-IX | iNeu™ Human Motor Neurons | NCL-2103-P62 | iNeu™ Human Sensory Neurons |
| NCL-21P6-003 | iNeu™ Human Midbrain Dopaminergic Neurons | NRZP-1122-ZP297 | iNeu™ Human GABAergic Neurons |
| NRZP-1122-ZP345 | iNeu™ Human Cholinergic Neurons | NCL-7P021 | iNeu™ GlutaNeurons |
| NCL-2103-P63 | iNeu™ Human Schwann Cells | NCL-2103-P70 | iNeu™ Human Retinal Pigment Epithelial Cells |
| NCL-2103-P73 | iNeu™ Human Keratinocytes | NRP-0322-P2185 | iNeu™ Human Sebocytes |
Reference
- Reich, Marvin et al. "Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia." Front Immunol. 2021, 11:617860.
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iNeu™ Retinal Pigment Epithelial Cells (RPE) [CAT#: NRZP-0323-ZP92]
- Species:
- Human
- Cell Types:
- Other Cells
iNeu™ Human Motor Neurons [CAT#: NCL-2103-P71]
- Species:
- Human
- Cell Types:
- Motor Neurons
iNeu™ Human Schwann Cell [CAT#: NCL-2103-P63]
- Species:
- Human
- Cell Types:
- Schwann Cells
iNeu™ Human Sensory Neurons [CAT#: NCL-2103-P62]
- Species:
- Human
- Cell Types:
- Sensory Neurons
iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) [CAT#: NCL-2103-P49]
- Species:
- Human
- Cell Types:
- Oligodendrocytes (OPC)
iNeu™ Human Neural Stem Cell Line [CAT#: NCL200552ZP]
A human neural stem cell line derived from human induced pluripotent stem cells.
- Species:
- Human
- Cell Types:
- Neural Stem Cells
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to Alzheimer Disease.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to Keratoconus.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to Spondylometaphyseal Displasia, Kozlowski Type.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to Charcot-Marie-Tooth Syndrome.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to Familial Alzheimer's Disease.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to Non-ALS MND.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS, Control, Isogenic Control.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to ALS.
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
An induced pluripotent stem cell (iPSC) line related to Skeletal Displasia.
- Species:
- Human
- Cell Types:
- iPSC
- NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody(NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- NeuroMab™ Anti-pTau Antibody(NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- NeuroMab™ Anti-TNFα BBB Shuttle Antibody(NRZP-1022-ZP4105) (Cat#: NRZP-1022-ZP4105)
- NeuroMab™ Anti-EPHB2 Antibody(NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- NeuroMab™ Anti-TREM2 Antibody(NRP-0422-P792) (Cat#: NRP-0422-P792)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- NeuroMab™ Anti-CD32b Antibody(NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2293) (Cat#: NRP-0422-P2293)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Human Neurons Isolated from Cortex (Cat#: NCL-21P6-023)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- pAAV-syn-FLEX-jGCaMP8f-WPRE (Cat#: NTA-2106-P064)
- AAV2/9-hSyn-Flpo-EGFP-WPRE-pA (Cat#: NTA-2012-ZP149)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- rAAV-E-SARE-Cre-ERT2-PEST-WPRE-hGH polyA (Cat#: NTA-2010-TT342)
- AAV-EF1a-mCherry-flex-dtA (Cat#: NRZP-0622-ZP616)
- AAV2/9-hEF1a-DIO-mCherry-P2A-TetTox-WPRE-pA (Cat#: NTA-2012-ZP268)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
