iPSC and iPSC-derived Cells
Induced pluripotent stem cells (iPSCs) are a type of stem cells that are generated from embryonic cells or adult somatic cells, such as mesenchymal stromal cells (MSCs), fibroblasts and peripheral blood mononuclear cells (PBMCs) through a process called reprogramming. This reprogramming involves introducing OCT4, SOX2, KLF4, and L-MYC genes by episomal plasmids or retroviral transduction that are essential for maintaining pluripotency. iPSCs have the remarkable ability to self-renew and develop into any type of somatic cell, making them valuable and powerful tools for disease modeling and drug discovery.
With a decade of expertise in the field, Creative Biolabs has built up advanced manufacturing capabilities for producing top-notch, functional iPSC and iPSC-derived cells with exceptional uniformity. If you are looking for iPSC-related cells, please feel free to contact us. We also provide made-to-order products with our lines or your lines.
Case Study
Microglia are immune cells found in the brain that help maintain the health and function of neural cells. Dysfunction in microglia has been linked to the development of neurodegenerative diseases, like Alzheimer's disease, where they may contribute to the progression of symptoms and cognitive decline.
We have optimized a culture protocol to generate single microglia from iPSCs, which specifically express Iba1, P2Y12, and TREM2, for modeling neurodegenerative and neuroinflammatory diseases.
Fig.1 Human iPSC-derived microglia stain positive for Iba1 (cyan), P2Y12 (yellow), and TREM2 (red).1
Trending Products
We are proud to offer a catalog of ready-to-ship iPSC and iPSC-derived cells from healthy or diseased patients (Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis) to help explore the research of neuroscience, pain, and sensation.
Cat. No. | Product Name | Cat. No. | Product Name |
NCL-2103-P85 | Human iPSC Line (Episomal, PBMC-derived) | NCL-2105-P121-IX | Human iPS Cell Line (Alzheimer's Disease) |
NCL-2105-P127-IX | Human iPS Cell Line (Parkinson's Disease) | NCL-2105-P126-IX | Human iPS Cell Line (Amyotrophic Lateral Sclerosis) |
NCL-2105-P128-IX | Human iPS Cell Line (SOD1 mutation, A4V, HOM) | NCL200552ZP | iNeu™ Human Neural Stem Cell Line |
NCL-2101-ZP09 | iNeu™ Human Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E) | NCL-2103-P80 | iNeu™ Human Neural Progenitor Cells |
NCL-7P030 | iNeu™ Astrocytes | NCL-7P018 | iNeu™ Microglia |
NCL-7P031 | iNeu™ Microglia AD APOE E4/E4 | NCL-2103-P78 | iNeu™ Human Cortical Neurons |
NRZP-1122-ZP263 | iNeu™ Human Striatal Neurons | NRP-0322-P2180 | iNeu™ Human Peripheral Neurons |
NCL-2105-P132-IX | iNeu™ Human Motor Neurons | NCL-2103-P62 | iNeu™ Human Sensory Neurons |
NCL-21P6-003 | iNeu™ Human Midbrain Dopaminergic Neurons | NRZP-1122-ZP297 | iNeu™ Human GABAergic Neurons |
NRZP-1122-ZP345 | iNeu™ Human Cholinergic Neurons | NCL-7P021 | iNeu™ GlutaNeurons |
NCL-2103-P63 | iNeu™ Human Schwann Cells | NCL-2103-P70 | iNeu™ Human Retinal Pigment Epithelial Cells |
NCL-2103-P73 | iNeu™ Human Keratinocytes | NRP-0322-P2185 | iNeu™ Human Sebocytes |
Reference
- Reich, Marvin et al. "Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia." Front Immunol. 2021, 11:617860. Distributed under Open Access License CC BY 4.0. The original image was modified.



- Species:
- Human
- Cell Types:
- Motor Neurons


- Species:
- Human
- Cell Types:
- Schwann Cells


- Species:
- Human
- Cell Types:
- Sensory Neurons


- Species:
- Human
- Cell Types:
- Oligodendrocytes (OPC)


- Species:
- Human
- Cell Types:
- Neural Stem Cells

- Species:
- Human
- Cell Types:
- Neurons

- Species:
- Human
- Cell Types:
- Neurons

- Species:
- Human
- Cell Types:
- Microglia

- Species:
- Human
- Cell Types:
- Microglia

- Species:
- Human
- Cell Types:
- Oligodendrocytes

- Species:
- Human
- Cell Types:
- Neurons

Expression of a broad panel of 5-HT receptors
- Species:
- Human
- Cell Types:
- Neurons

- Species:
- Human
- Cell Types:
- BBB-related Cells

Positive for GFAP, ALDH1L1
- Species:
- Human
- Cell Types:
- Astrocytes

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC

Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Rat Muller Cell (Cat#: NCL2110P040)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Immortalized Human Cerebral Microvascular Endothelial Cells (Cat#: NCL-2108-P020)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- iNeu™ Human Sensory Neurons (Cat#: NCL-2103-P62)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)