iPSC and iPSC-derived Cells
Induced pluripotent stem cells (iPSCs) are a type of stem cells that are generated from embryonic cells or adult somatic cells, such as mesenchymal stromal cells (MSCs), fibroblasts and peripheral blood mononuclear cells (PBMCs) through a process called reprogramming. This reprogramming involves introducing OCT4, SOX2, KLF4, and L-MYC genes by episomal plasmids or retroviral transduction that are essential for maintaining pluripotency. iPSCs have the remarkable ability to self-renew and develop into any type of somatic cell, making them valuable and powerful tools for disease modeling and drug discovery.
With a decade of expertise in the field, Creative Biolabs has built up advanced manufacturing capabilities for producing top-notch, functional iPSC and iPSC-derived cells with exceptional uniformity. If you are looking for iPSC-related cells, please feel free to contact us. We also provide made-to-order products with our lines or your lines.
Case Study
Microglia are immune cells found in the brain that help maintain the health and function of neural cells. Dysfunction in microglia has been linked to the development of neurodegenerative diseases, like Alzheimer's disease, where they may contribute to the progression of symptoms and cognitive decline.
We have optimized a culture protocol to generate single microglia from iPSCs, which specifically express Iba1, P2Y12, and TREM2, for modeling neurodegenerative and neuroinflammatory diseases.
Fig.1 Human iPSC-derived microglia stain positive for Iba1 (cyan), P2Y12 (yellow), and TREM2 (red).1
Trending Products
We are proud to offer a catalog of ready-to-ship iPSC and iPSC-derived cells from healthy or diseased patients (Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis) to help explore the research of neuroscience, pain, and sensation.
| Cat. No. | Product Name | Cat. No. | Product Name |
| NCL-2103-P85 | Human iPSC Line (Episomal, PBMC-derived) | NCL-2105-P121-IX | Human iPS Cell Line (Alzheimer's Disease) |
| NCL-2105-P127-IX | Human iPS Cell Line (Parkinson's Disease) | NCL-2105-P126-IX | Human iPS Cell Line (Amyotrophic Lateral Sclerosis) |
| NCL-2105-P128-IX | Human iPS Cell Line (SOD1 mutation, A4V, HOM) | NCL200552ZP | iNeu™ Human Neural Stem Cell Line |
| NCL-2101-ZP09 | iNeu™ Human Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E) | NCL-2103-P80 | iNeu™ Human Neural Progenitor Cells |
| NCL-7P030 | iNeu™ Astrocytes | NCL-7P018 | iNeu™ Microglia |
| NCL-7P031 | iNeu™ Microglia AD APOE E4/E4 | NCL-2103-P78 | iNeu™ Human Cortical Neurons |
| NRZP-1122-ZP263 | iNeu™ Human Striatal Neurons | NRP-0322-P2180 | iNeu™ Human Peripheral Neurons |
| NCL-2105-P132-IX | iNeu™ Human Motor Neurons | NCL-2103-P62 | iNeu™ Human Sensory Neurons |
| NCL-21P6-003 | iNeu™ Human Midbrain Dopaminergic Neurons | NRZP-1122-ZP297 | iNeu™ Human GABAergic Neurons |
| NRZP-1122-ZP345 | iNeu™ Human Cholinergic Neurons | NCL-7P021 | iNeu™ GlutaNeurons |
| NCL-2103-P63 | iNeu™ Human Schwann Cells | NCL-2103-P70 | iNeu™ Human Retinal Pigment Epithelial Cells |
| NCL-2103-P73 | iNeu™ Human Keratinocytes | NRP-0322-P2185 | iNeu™ Human Sebocytes |
Reference
- Reich, Marvin et al. "Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia." Front Immunol. 2021, 11:617860. Distributed under Open Access License CC BY 4.0. The original image was modified.
Loading...
iNeu™ Human Motor Neurons [CAT#: NCL-2103-P71]
- Species:
- Human
- Cell Types:
- Motor Neurons
iNeu™ Human Schwann Cell [CAT#: NCL-2103-P63]
- Species:
- Human
- Cell Types:
- Schwann Cells
iNeu™ Human Sensory Neurons [CAT#: NCL-2103-P62]
- Species:
- Human
- Cell Types:
- Sensory Neurons
iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) [CAT#: NCL-2103-P49]
- Species:
- Human
- Cell Types:
- Oligodendrocytes (OPC)
iNeu™ Human Neural Stem Cell Line [CAT#: NCL200552ZP]
- Species:
- Human
- Cell Types:
- Neural Stem Cells
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
- iNeuMab™ Anti-FGFR1 Antibody (NRP-0422-P1244) (Cat#: NRP-0422-P1244)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Anti-GD2 Antibody (NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- iNeuMab™ Anti-SEZ6 Antibody (NRP-0422-P515) (Cat#: NRP-0422-P515)
- iNeuMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody (NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Anti-Amyloid Beta 1-15 Antibody (NRP-0422-P867) (Cat#: NRP-0422-P867)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Anti-SEZ6 Antibody (NRP-0422-P517) (Cat#: NRP-0422-P517)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Rat Muller Cell (Cat#: NCL2110P040)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Immortalized Human Cerebral Microvascular Endothelial Cells (Cat#: NCL-2108-P020)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Mouse Retinal Ganglion Cells (Cat#: NCL2110P145)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- iNeu™ Human Sensory Neurons (Cat#: NCL-2103-P62)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
