iPSC and iPSC-derived Cells
Induced pluripotent stem cells (iPSCs) are a type of stem cells that are generated from embryonic cells or adult somatic cells, such as mesenchymal stromal cells (MSCs), fibroblasts and peripheral blood mononuclear cells (PBMCs) through a process called reprogramming. This reprogramming involves introducing OCT4, SOX2, KLF4, and L-MYC genes by episomal plasmids or retroviral transduction that are essential for maintaining pluripotency. iPSCs have the remarkable ability to self-renew and develop into any type of somatic cell, making them valuable and powerful tools for disease modeling and drug discovery.
With a decade of expertise in the field, Creative Biolabs has built up advanced manufacturing capabilities for producing top-notch, functional iPSC and iPSC-derived cells with exceptional uniformity. If you are looking for iPSC-related cells, please feel free to contact us. We also provide made-to-order products with our lines or your lines.
Case Study
Microglia are immune cells found in the brain that help maintain the health and function of neural cells. Dysfunction in microglia has been linked to the development of neurodegenerative diseases, like Alzheimer's disease, where they may contribute to the progression of symptoms and cognitive decline.
We have optimized a culture protocol to generate single microglia from iPSCs, which specifically express Iba1, P2Y12, and TREM2, for modeling neurodegenerative and neuroinflammatory diseases.
Fig.1 Human iPSC-derived microglia stain positive for Iba1 (cyan), P2Y12 (yellow), and TREM2 (red).1
Trending Products
We are proud to offer a catalog of ready-to-ship iPSC and iPSC-derived cells from healthy or diseased patients (Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis) to help explore the research of neuroscience, pain, and sensation.
| Cat. No. | Product Name | Cat. No. | Product Name |
| NCL-2103-P85 | Human iPSC Line (Episomal, PBMC-derived) | NCL-2105-P121-IX | Human iPS Cell Line (Alzheimer's Disease) |
| NCL-2105-P127-IX | Human iPS Cell Line (Parkinson's Disease) | NCL-2105-P126-IX | Human iPS Cell Line (Amyotrophic Lateral Sclerosis) |
| NCL-2105-P128-IX | Human iPS Cell Line (SOD1 mutation, A4V, HOM) | NCL200552ZP | iNeu™ Human Neural Stem Cell Line |
| NCL-2101-ZP09 | iNeu™ Human Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E) | NCL-2103-P80 | iNeu™ Human Neural Progenitor Cells |
| NCL-7P030 | iNeu™ Astrocytes | NCL-7P018 | iNeu™ Microglia |
| NCL-7P031 | iNeu™ Microglia AD APOE E4/E4 | NCL-2103-P78 | iNeu™ Human Cortical Neurons |
| NRZP-1122-ZP263 | iNeu™ Human Striatal Neurons | NRP-0322-P2180 | iNeu™ Human Peripheral Neurons |
| NCL-2105-P132-IX | iNeu™ Human Motor Neurons | NCL-2103-P62 | iNeu™ Human Sensory Neurons |
| NCL-21P6-003 | iNeu™ Human Midbrain Dopaminergic Neurons | NRZP-1122-ZP297 | iNeu™ Human GABAergic Neurons |
| NRZP-1122-ZP345 | iNeu™ Human Cholinergic Neurons | NCL-7P021 | iNeu™ GlutaNeurons |
| NCL-2103-P63 | iNeu™ Human Schwann Cells | NCL-2103-P70 | iNeu™ Human Retinal Pigment Epithelial Cells |
| NCL-2103-P73 | iNeu™ Human Keratinocytes | NRP-0322-P2185 | iNeu™ Human Sebocytes |
Reference
- Reich, Marvin et al. "Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia." Front Immunol. 2021, 11:617860. Distributed under Open Access License CC BY 4.0. The original image was modified.
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iNeu™ Human Motor Neurons [CAT#: NCL-2103-P71]
- Species:
- Human
- Cell Types:
- Motor Neurons
iNeu™ Human Schwann Cell [CAT#: NCL-2103-P63]
- Species:
- Human
- Cell Types:
- Schwann Cells
iNeu™ Human Sensory Neurons [CAT#: NCL-2103-P62]
- Species:
- Human
- Cell Types:
- Sensory Neurons
iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) [CAT#: NCL-2103-P49]
- Species:
- Human
- Cell Types:
- Oligodendrocytes (OPC)
iNeu™ Human Neural Stem Cell Line [CAT#: NCL200552ZP]
- Species:
- Human
- Cell Types:
- Neural Stem Cells
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
Disease Model Cells, Clinical Samples
- Species:
- Human
- Cell Types:
- iPSC
- iNeuMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody (NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- iNeuMab™ Anti-Alpha Synuclein Antibody (NRP-0422-P614) (Cat#: NRP-0422-P614)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P1760) (Cat#: NRP-0422-P1760)
- iNeuMab™ Anti-Alpha Synuclein BBB Shuttle Antibody (NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- iNeuMab™ Anti-SEZ6 Antibody (NRP-0422-P515) (Cat#: NRP-0422-P515)
- iNeuMab™ Anti-ApoC3 BBB Shuttle Antibody (NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Anti-CD20 Antibody (NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Anti-GD2 Antibody (NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Human Glial (Oligodendrocytic) Hybrid Cell Line (MO3.13) (Cat#: NCL-2108P34)
- Rat Muller Cell (Cat#: NCL2110P040)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
