Neural Marker Antibodies
Neurons are the primary structural and functional components of the nervous system, featuring four distinct morphological components: the cell body (soma), dendrites, an axon, and presynaptic terminals. The soma is the core of cell metabolism and contains the nucleus and other organelles containing the cell's DNA. Dendrites are receivers of incoming signals. Axons generate outgoing signals. Presynaptic terminals, which contain vesicles containing neurotransmitters, are found at the ends of each axon branch. Neuronal cells are highly polarized and collect information from upstream neurons or the environment via dendritic branches, while axons send integrated information to downstream neurons or non-neuronal cells (such as muscles) via synapses.
Studying nerve cells with various functions is a vital first step in understanding how the neurological system operates. Researchers can easily identify neurons with distinct roles using antibodies targeting these neuronal markers. Additionally, researchers can:
- Examine the morphology and phenotype of neurons
- Evaluating co-localization of proteins
- Displaying synaptic connections visually
- Quantify the expression of proteins
- Determine the state of cell development
Markers of Neural Structure
Creative Biolabs provides antibodies against markers that are expressed precisely in each structural unit of neurons.
Structural Unit | Markers |
Nuclear Markers | c-Fos , FUS , HDAC1 , HDAC2 , HDAC3 , HDAC8 , NeuN , MECP2 , PCNA , STAT3 |
Soma Markers | NSE , Tyrosine Hydroxylase |
Dendrite Markers | MAP2 |
Axon Markers | Neurofilament L , Neurofilament M , Neurofilament M/H , Neurofilament H , Pan-Neurofilament, Tau |
Axon, Dendrite, and Soma Markers | α-Tubulin , β-Actin , β3-Tubulin |
Presynaptic Markers | Ankyrin-B , Cask , GRK , Snap-25 , Stonin-2 , SVOP , Synapsin , Synaptobrevin (VAMP) , Synaptophysin , Synaptotagmin-3 , Synaptotagmin-6 , Synaptotagmin-12 , Syntaxin , VGlut1 , VGlut2 , Wave1 |
Postsynaptic Markers | ADAM22 , ASIC1 , IP3R1 , Maguk , Neurogranin , PSD93 , PSD95 , SAP102 , SAP97 , SAPAP , Shank , SynDIG1 , Thorase |
Myelin Sheath Markers | Myelin Basic Protein , Myelin CNPase |
Summary of Various Neuronal Markers
We also offer reliable labeling antibodies for different kinds and stages of neurons.
Neuron Types | Markers |
Neuroepithelial cells | Nestin , SOX2 , notch1 , HES1 , HES3, E-Cadherin , occludin |
Immature neurons | Doublecortin , β3-Tubulin , NeuroD1 , TBR1 , stathmin 1 , DCX |
Mature neurons | NeuN , MAP2 , 160kDa neurofilament medium , 200kDa neurofilament heavy , synaptophysin , PSD95 |
Glutamatergic neurons | vGluT1 , vGluT2 , NMDAR1 , NMDAR2B , Glutaminase , Glutamine synthetase |
GABAergic neurons | GABA transporter 1 , GABAB receptor 1 , GABAB receptor 2 , GAD65 , GAD67 |
Dopaminergic neurons | Tyrosine Hydroxylase , Dopamine Transporter , FOXA2 , GIRK2 , Nurr1 , LMX1B |
Serotonergic neurons | Tryptophan Hydroxylase , Serotonin Transporter , Pet1 |
Cholinergic neurons | Choline Acetyltransferase , Acetylcholine Transporter , Acetylcholinesterase |
Additional Neuronal Markers | Polysialic acid-neural cell adhesion molecule (PSA-NCAM) , Neurogenic Differentiation 1 (NeuroD or Beta2) , Calbindin-D28k , Calretinin , Synaptoporin (SYNPR, SPO) |
Glial Cell Markers
Aside from the neurons that make up the central or peripheral nervous system, there is another type of non-neuronal cell called glial cells that offer structural and metabolic support to neurons. Glial cells consist of:
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