NeuroMab™ Anti-Kir2.3 potassium channel BBB Shuttle Antibody, Clone N25/35

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNJ4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 390-445 (cytoplasmic C-terminus, EAAAAAAVA AGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI) of human Kir2.3 (also known as Inward rectifier potassium channel subfamily J member 4, KCNJ4, Brain inwardly rectifying K(+) channel 2, Hippocampal inward rectifier, HIRK2, HRK1, HIR, IRK3 and BIR11, accession number P48050)
Mouse: 94% identity (54/57 amino acids identical)
Rat: 94% identity (54/57 amino acids identical)
<50% identity with Kir2.1 and Kir2.2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N25/35

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Kir2.1 or Kir2.2

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNJ4

Official Name

KCNJ4

Full Name

Kir2.3 K+ channel

Alternative Names

KCNJ4; HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3; potassium voltage-gated channel subfamily J member 4; potassium inwardly rectifying channel subfamily J member 4

Uniprot ID

P48050

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N25/35 (left) or N52A/42 (right) TC supe.