NeuroMab™ Anti-Shank3 BBB Shuttle Antibody, Clone N367/62

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SHANK3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 538-626 (SH3 domain) of rat Shank3 (also known as SH3 and multiple ankyrin repeat domains protein 3, Proline-rich synapse-associated protein 2, ProSAP2, PSAP2, SPANK-2 and Kiaa1650, accession number Q9JLU4)
Mouse: 100% identity (89/89 amino acids identical)
Human: 97% identity (87/89 amino acids identical)
~70% identity with Shank1 and Shank2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N367/62

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Shank1 or Shank2

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SHANK3

Official Name

SHANK3

Full Name

Shank3

Alternative Names

SH3 And Multiple Ankyrin Repeat Domains 3; Proline Rich Synapse Associated Protein 2; Shank Postsynaptic Density Protein; PROSAP2; PSAP2; SH3 And Multiple Ankyrin Repeat Domains Protein 3; Proline-Rich Synapse-Associated Protein 2;

Uniprot ID

Q9JLU4

Product Pictures

Fig. 1 Immunoblot against adult rat brain membranes (RBM) and membranes from Shank3 wild-type (WT) and knockout (KO) mice probed with N367/62 (left) or K58/35 (right) TC supe.

Fig. 2 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Shank1, Shank2, Shank3 or untagged Kv2.1 plasmid and probed with N367/62 (left) or N23B/49 (right) TC supe.