NeuroMab™ Anti-Shank3 scaffold protein BBB Shuttle Antibody, Clone N69/46

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SHANK3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 840-857 (PEKLPGSLRKGIPRTKSV) of rat Shank3 (also known as SH3 and multiple ankyrin repeat domains protein 3, prolinerich synapse-associated protein 2, ProSAP2 and SPANK-2, accession number Q9JLU4)
Human: 100% identity (18/18 amino acids identical)
Mouse: 100% identity (18/18 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N69/46

Applications

WB; IHC; IP; ICC

Application Notes

No cross-reactivity against Shank1 or Shank2

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SHANK3

Official Name

SHANK3

Full Name

Shank3

Alternative Names

SH3 And Multiple Ankyrin Repeat Domains 3; Proline Rich Synapse Associated Protein 2; Shank Postsynaptic Density Protein; PROSAP2; PSAP2; SH3 And Multiple Ankyrin Repeat Domains Protein 3; Proline-Rich Synapse-Associated Protein 2;

Uniprot ID

Q9JLU4

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with Shank1, Shank2, Shank3 or Kv2.1 plasmids and probed with N69/46 TC supe (left panel) or a monoclonal lane loading control (right panel)