NeuroMab™ Anti-VAChT BBB Shuttle Antibody, Clone N425/45
[CAT#: NRZP-0423-ZP454]
- Species Reactivity:
- Rat; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VAChT BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 55-125 (first vesicle lumen domain) of rat VAChT (also known as Vesicular acetylcholine transporter, Solute carrier family 18 member 3, Vat and Slc18a3, accession number Q62666)
Mouse: 97% identity (69/71 amino acids identical)
Human: 84% identity (60/71 amino acids identical)
<40% identity with VMAT1 and other vesicular transporters
Mouse: 97% identity (69/71 amino acids identical)
Human: 84% identity (60/71 amino acids identical)
<40% identity with VMAT1 and other vesicular transporters
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N425/45
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with VMAT1 or VMAT2
Research Areas
Transporters
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
VAChT
Official Name
SLC18A3
Full Name
VAChT
Alternative Names
SLC18A3; VACHT; solute carrier family 18 member A3; CMS21
Uniprot ID
Q62666
Product Pictures
IHC
Fig. 1 Adult rat trigeminal and facial motor nuclei immunohistochemistry.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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