NeuroMab™ Rat Anti-CD204 Monoclonal Antibody (CBP2568)

Product Overview

Description

The rat anti-Mouse CD204 antibody recognizes type I and type II mouse scavenger receptor A (SRA), also known as CD204. CD204 is expressed by tissue macrophages and serves both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages to bind to ligand-rich tissues (eg, macrophages). Atherosclerotic lesions. The rat anti-Mouse CD204 antibody, recognizes an epitope in SRA, which is polymorphic in SRA of C57BL/6 mice. The rat anti-Mouse CD204 antibody clone 2F8 is therefore not suitable for use with the C57BL/6 mouse strain (Daugherty et al. 2000).

Immunogen

Original 264 cell line.

Species Reactivity

Mouse; Porcine; Channel catfish

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b

Clone Number

CBP2568

Applications

Application Notes

FC: 1/5

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1869

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.05 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MSR1

Official Name

Msr1

Full Name

Macrophage Scavenger Receptor 1

Alternative Names

Macrophage Scavenger Receptor 1; Macrophage Acetylated LDL Receptor I And II; Scavenger Receptor Class A Member 1; SCARA1; Macrophage Scavenger Receptor Types I And II; Macrophage Scavenger Receptor Type III; CD204 Antigen; SR-AIII;

Gene ID

4481(Human); 20288(Mouse); 498638(Rat)

Uniprot ID

P21757(Human); P30204(Mouse)

References

1. de Villiers, W.J. et al. (1994) Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
2. Hughes, D.A. et al. (1995) Murine macrophage scavenger receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs.
3. Gordon, S. (1995) The macrophage.
4. Hughes, D.A. et al. (1994) Murine M phi scavenger receptor: adhesion function and expression.
5. Aid, S. et al. (2008) Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2.

Publications