NeuroMab™ Anti-Cavβ4 calcium channel BBB Shuttle Antibody, Clone N10/7

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNB4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 458-474 of rat Cavβ4 (DENYHNERARKSRNRLS; XP_215742)
Human: 100% identity
Mouse=100% identity

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N10/7

Applications

WB; IHC; IP; ICC

Application Notes

No crossreactivity against rat Cavβ1b, Cavβ2a, and Cavβ3 in transfected cells

Research Areas

Ca2+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CACNB4

Official Name

CACNB4

Full Name

Cavbeta4 Ca2+ channel

Alternative Names

CACNB4; Calcium channel; voltage-dependent; beta 4 subunit

Uniprot ID

XP_215742

Product Pictures

Fig. 1 Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and lethargic (lh/lh) mice (left) Lethargic mice courtesy of Dr. Jeff Noebels, Baylor College of Medicine.

Fig. 2 Adult rat brain membrane immunoblot.

Fig. 3 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].