NeuroMab™ Anti-GFAP-R416WT BBB Shuttle Antibody, Clone N206B/9
[CAT#: NRZP-0423-ZP137]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
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SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GFAP BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Synthetic peptide amino acids 411-422 (KTVEMRDGEVIK) of human GFAP (also known as Glial fibrillary acidic protein, accession number P14136)
Rat: 100% identity (12/12 amino acids identical)
Mouse: 100% identity (12/12 amino acids identical)
>50% identity with other proteins (Vimentin, Desmin and Peripherin)
Rat: 100% identity (12/12 amino acids identical)
Mouse: 100% identity (12/12 amino acids identical)
>50% identity with other proteins (Vimentin, Desmin and Peripherin)
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N206B/9
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with GFAP-R416W or other proteins (based on KO validation results)
Research Areas
Rare Disease
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GFAP
Official Name
GFAP
Full Name
GFAP R416WT
Alternative Names
Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;
Uniprot ID
P14136
Product Pictures
IB
Fig. 1 Immunoblot versus brain samples from adult rat (RBLSP) and GFAP wildtype (WT), knockout (KO) and R416W KI mice.
IF
Fig. 2 Immunofluorescence of GFAP WT and KO mouse hippocampus with N206B/9 (green) and KC rabbit antiKv2.1 (red).
IB
Fig. 3 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Genes
Neural Antibodies
Kits
For Research Use Only. Not For Clinical Use.
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