NeuroMab™ Anti-LRRK2/Dardarin-pSer910 BBB Shuttle Antibody, Clone 1D8

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-LRRK2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 904-917 (VKKKSN[pS]ISVGEFY) of human LRRK2 (also known as Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin and PARK8, accession number Q5S007)
Mouse: 85% identity (12/14 amino acids identical)
Rat: 85% identity (12/14 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

1D8

Applications

ELISA; DB; ICC; WB

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

LRRK2

Official Name

LRRK2

Full Name

LRRK2/Dardarin-pSer910

Alternative Names

LRRK2; AURA17; DARDARIN; PARK8; RIPK7; ROCO2; leucine-rich repeat kinase 2; leucine rich repeat kinase 2

Uniprot ID

Q5S007

Product Pictures

Fig. 1 Endogenous and transfected cell immunoblot: extracts of HEK-293 cells transfected with GFP-tagged LRRK2-WT, LRRK2-S910A or LRRK2-S935A plasmid; fibroblasts from embryonic WT or LRRK2 KO mice untreated or treated with LRRK2-IN-1 inhibitor; and human lymphoblasts untreated or treated with LRRK2-IN-1, probed with 1D8.

Publications