NeuroMab™ Anti-VGlut2 BBB Shuttle Antibody, Clone N29/29

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VGLUT2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 501-582 (cytoplasmic C-terminus) of rat VGlut2 (also known as Vesicular glutamate transporter 2, Differentiation-associated BNPI, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Dnpi, Solute carrier family 17 member 6 and Slc17a6, accession number Q9JI12)
Mouse: 97% identity (80/82 amino acids identical)
Human: 89% identity (73/82 amino acids identical)
<50% identity with VGlut1 or VGlut3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N29/29

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with VGlut1 or VGlut3

Research Areas

Transporters

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

VGLUT2

Official Name

SLC17A6

Full Name

VGlut2

Alternative Names

Vesicular glutamate transporter 2

Uniprot ID

Q9JI12

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged VGlut1, VGlut2, VGlut3 or Kv2.1 plasmid and probed with N29/29 (left) or N52A/42 (right) TC supe.

Fig. 2 Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with N29/29 (left) and N52A/42 (right) TC supe.