NeuroMab™ Anti-VGlut3 BBB Shuttle Antibody, Clone N34/34

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Slc17a8 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 546-588 (cytoplasmic C-terminus) of rat VGlut3 (also known as Vesicular glutamate transporter 3, Solute carrier family 17 member 8 and Slc17a8, accession number Q7TSF2)
Mouse: 88% identity (38/43 amino acids identical)
Human: 59% identity (26/44 amino acids identical)
<50% identity with VGlut1 or VGlut2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N34/34

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with VGlut1 or VGlut2

Research Areas

Transporters

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Slc17a8

Official Name

SLC17A8

Full Name

VGlut3

Alternative Names

DFNA25 Antibody, Vesicular glutamate transporter 3 Antibody, deafness autosomal dominant 25 Antibody, SLC17A8 Antibody, Solute carrier family 17 member 8 Antibody, VGLUT 3 Antibody, Solute carrier family 17 (sodium dependent inorganic phosphate cotransporter) member 8 Antibody; Solute Carrier Family 17 Member 8; Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 8; Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 8; Vesicular Glutamate Transporter 3; VGLUT3; Deafness, Autosomal Dominant 25; DFNA25

Uniprot ID

Q7TSF2

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of CV-1 fibroblast cells transfected with VGlut3 (+) or left untransfected (-) and probed with N34/34 TC supe.

Fig. 2 Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged VGlut1, VGlut2, VGlut3 or Kv2.1 plasmid and probed with N34/34 (left) or N52A/42 (right) TC supe.