NeuroMab™ Mouse Anti-Human ALDH1L1 Monoclonal Antibody (CBP2354)

Product Overview

Description

Aldehyde dehydrogenase family 1 member L1 (ALDH1L1) was originally discovered as an enzyme that catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate, with NADPH and CO2 as by products. ALDH1L1 is most exclusively expressed by astroglial cells1 implicating these cells as the major components of folate-dependent formate oxidation in the brain.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2354

Applications

Application Notes

WB (0.2-5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1738

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

ALDH1L1

Official Name

ALDH1L1

Full Name

Aldehyde Dehydrogenase 1 Family Member L1

Alternative Names

FDH

Gene ID

10840 (Human); 107747 (Mouse); 64392 (Rat)

Uniprot ID

O75891 (Human); Q8R0Y6 (Mouse); P28037 (Rat)

References

1. Neymerer V, et al. 1997. Brain Res. 766(1-2): 195
2. Brandebura AN, et al. 2018. Dev Neurobiol. doi: 10.1002/dneu.22633.
3. Garwood CJ, et al. 2017. Neuropathol Appl Neurobiol. 43(4):281

Publications