NeuroMab™ Anti-KChIP1 potassium channel BBB Shuttle Antibody, Clone K55/7

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNIP1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-227 (full-length) of rat KChIP1b (also known as Kcnip1, Kv channelinteracting protein 1, Potassium channel-interacting protein 1, A-type potassium channel modulatory protein 1, Vesicle APC-binding protein and VABP, accession number Q8R426)
Mouse: 99% identity (226/227 amino acids identical)
Human: 99% identity (225/227 amino acids identical)
>50% identity with KChIP2, KChIP3 and KChIP4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K55/7

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with KChIP2, KChIP3 or KChIP4

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNIP1

Official Name

KCNIP1

Full Name

KChIP1 K+ channel

Alternative Names

VABP; KCHIP1

Uniprot ID

Q8R426

Product Pictures

Fig. 1 Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with K55/7 (left), K55/82 (middle) and N52A/42 (right).