NeuroMab™ Anti-Nav1.7 BBB Shuttle Antibody(NRZP-1022-ZP2481)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

The antibody binds to Human and Mouse domain B.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Rabbit

Applications

ELISA; Block; Inhib; In Vivo; In Vitro

Relevant Diseases

Pain; Epilepsy

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

SCN9A

Official Name

SCN9A

Full Name

sodium voltage-gated channel alpha subunit 9

Alternative Names

SCN9A; ETHA; FEB3B; GEFSP7; HSAN2D; NE-NA; NENA; Nav1.7; PN1; SFNP; sodium voltage-gated channel alpha subunit 9

Product Pictures

FuncS

Fig.1 shows that the 932 and 983 anti-Nav1.7 monoclonal antibodies reduce electrically induced DRG spike frequency in vitro.

PBS1x, recombinant S100A9, C-terminal and C1 to C7 peptide peptides (50 ng/well) were coated on 96 well plates. 100 μl of the cell culture supernatant of 11 rabbit blocking anti-S100A9 was added to the wells. Binding of monoclonal antibodies was revealed using an HRP-labeled goat anti-rabbit IgG antibody. Both mAbs bind to the C7 peptide.

FuncS

Fig.2 shows that anti-Nav1.7 monoclonal antibody 983 reduces electrically induced DRG spike frequency in vitro.

FuncS

Fig.3 a shows automated Patch Clamp analysis of recombinant human Nav1.7 channels expressed in HEK cells. 983 monoclonal antibody produces a dose-dependent inhibition of Nav1.7 currents.