NeuroMab™ Anti-REEP1 BBB Shuttle Antibody, Clone N345/51

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-REEP1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 111-201 (KDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRS FSMQDLTTIRGDGAPAPSGPPPPGTGRSSGKHSQPKMSRSASESAGSSGTA, cytoplasmic C-terminus) of mouse REEP1 (also known as Receptor expression-enhancing protein 1, C2orf23, D6Ertd253e and rCG_56072, accession number Q8BGH4)
Rat: 97% identity (89/91 amino acids identical)
Human: 95% identity (87/91 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N345/51

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

REEP1

Official Name

REEP1

Full Name

REEP1

Alternative Names

Receptor Accessory Protein 1; Spastic Paraplegia 31 Protein; C2orf23; SPG31; Receptor Expression Enhancing Protein 1; Receptor Expression-Enhancing Protein 1; Chromosome 2 Open Reading Frame 23; HMN5B; Yip2a;

Uniprot ID

Q8BGH4

Product Pictures

Fig. 1 Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Flagtagged REEP1, REEP2 or untagged Kv2.1 plasmid and probed with N345/51 (left) and K89/34 (right) TC supe.

IHC

Fig. 2 Adult rat brain immunohistochemistry (with antigen retrieval via sodium citrate pretreatment).

Fig. 3 Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebellum [HBM(Cb)] or cerebral cortex [HBM(Cx)] and probed with N345/51 (left) or N52A/42 (right) TC supe.

Publications