NeuroMab™ Anti-TfR1 BBB Shuttle Antibody(NRZP-1222-ZP1098)
[CAT#: NRZP-1222-ZP1098]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Block; Inhib; In Vitro
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
Pathogenic clade B New World mammarenaviruses (NWM) can cause Argentine, Venezuelan, Brazilian, and Bolivian hemorrhagic fevers. Blockade of their shared binding site on the apical domain of human transferrin receptor 1 (hTfR1/CD71) presents an opportunity for the development of effective and broadly neutralizing therapeutics. The murine monoclonal antibody OKT9, which targets the apical domain of hTfR1, can sterically block cellular entry by viral particles presenting clade B NWM glycoproteins (GP1-GP2).
Species Reactivity
Human
Host Species
Mouse
Applications
Block; Inhib; In Vitro
Relevant Diseases
Tumor
Target
Target
TransferrinReceptor
Official Name
TfR
Full Name
Transferrin Receptor
Alternative Names
CD71; TFR1
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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