NeuroMab™ Anti-TrpC5 calcium channel BBB Shuttle Antibody, Clone N67/15

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-TRPC5 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 827-845 (SKAESSSKRSFMGPSLKKL) of human TrpC5 (also known as short transient receptor potential channel 5 and Htrp5, accession number Q9UL62)
Mouse: 88% identity (16/18 amino acids identical)
Rat: 88% identity (16/18 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N67/15

Applications

WB; IHC; IP; ICC

Research Areas

Trp channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

TRPC5

Official Name

TRPC5

Full Name

TrpC5

Alternative Names

Transient Receptor Potential Cation Channel Subfamily C Member 5; Protein Phosphatase 1; Regulatory Subunit 159; Transient Receptor Protein 5; TRP-5; HTRP5; TRP5; Transient Receptor Potential Cation Channel; Subfamily C; Member 5;

Uniprot ID

Q9UL62

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells transiently transfected with TrpC5 and Kv2.1 plasmids and probed with N67/15 (left) or K89/34 (right) TC supe.