NeuroMab™ Anti-VGlut1 BBB Shuttle Antibody, Clone N28/9

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VGlut1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 493-560 (cytoplasmic C-terminus) of rat VGlut1 (also known as Vesicular glutamate transporter 1, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Bnpi, Solute carrier family 17 member 7 and Slc17a7, accession number Q62634)
Mouse: 97% identity (66/68 amino acids identical)
Human: 95% identity (65/68 amino acids identical)
<50% identity with VGlut2 or VGlut3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N28/9

Applications

WB; IHC; ICC

Application Notes

Does not react with VGlut2 or VGlut3

Research Areas

Transporters

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

VGlut1

Official Name

SLC17A7

Full Name

VGlut1

Alternative Names

SLC17A7; BNPI; VGLUT1; solute carrier family 17 member 7

Uniprot ID

Q62634

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transfected with untagged VGlut or Kv2.1 plasmid and probed with N28/9 (left) or N52A/42 (right) TC supe.