Mouse Anti-SLC17A7 Monoclonal Antibody (CBP6783)

Description

Synaptic signaling is the communication between cells that occurs at the synaptic level. Cells communicate with each other through direct contact (near secretory signals), short distances (paracrine signals), or long distances and scales (endocrine signals). Other cells form gap junctions, connecting their cytoplasm to The cytoplasm of adjacent cells. When the sending neuron is activated, the electrical impulse will propagate with it Axon. Once the impulse reaches the synapse, it triggers the release of neurotransmitters. The main excitatory neurotransmitter in the brain is glutamate (GLU). The inhibitory neurotransmitters GABA (in the brain) and glycine (in the brain stem and spinal cord) are common Amino acids involved in multiple metabolic cycles. Vesicular glutamate transporter 1 (VGLUT1) is a protein encoded by the SLC17A7 gene in humans.
The protein encoded by this gene is a vesicle-bound sodium-dependent phosphate transporter specifically expressed in the neuron-rich region of the brain. It is preferably associated with the membrane of synaptic vesicles and plays a role in glutamate transport. This protein is 82% identical to the differentiation-dependent Na-dependent inorganic phosphate co-transporter and appears to form a unique category in the Na + /Pi co-transporter family.

Epitope

Binds to an located within the peptide sequence EERKYIEDAI

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6783

Applications

IHC; WB

Application Notes

IHC: 1:5000-1:10000
WB: 1 µg/ml

Research Areas

Neurotransmitter

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

VGlut1

Official Name

SLC17A7

Full Name

Vesicular glutamate transporter 1

Alternative Names

SLC17A7; BNPI; VGLUT1; solute carrier family 17 member 7

Gene ID

57030(Human); 72961(Mouse); 116638(Rat)

Uniprot ID

Q9P2U7(Human); Q3TXX4(Mouse); Q62634(Rat)