Product
NeuroMab™ Mouse Anti-GFAP Monoclonal Antibody (CBP1572)
[CAT#: NAB2007FY144]
Mouse Monoclonal [2E1] to GFAP
- Host Species:
- Mouse
- Species Reactivity:
- Bovine; Human; Mouse; Rat; Sheep; Dog; Porcine; Rabbit; Guinea Porcine; Chicken
- Applications:
- IHC-P; IHC-Fr; WB; RIA
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Mouse anti-bovine GFAP antibody can recognize glial fibrillary acidic protein or GFAP (class III intermediate filament). During the development of the central nervous system, GFAP distinguishes astrocytes from other glial cells. It involves various cell functions, such as cell structure and movement, cell communication and the function of the blood-brain barrier. It also plays a role in mitosis by regulating the network of filaments present in the cell.
GFAP deficiency is the cause of Alexander disease, a rare central nervous system disease that mainly affects men. It is a progressive leukoencephalopathy that causes mental and physical development delays, dementia, seizures and early death.
GFAP deficiency is the cause of Alexander disease, a rare central nervous system disease that mainly affects men. It is a progressive leukoencephalopathy that causes mental and physical development delays, dementia, seizures and early death.
Immunogen
Bovine spinal cord homogenate.
Species Reactivity
Bovine; Human; Mouse; Rat; Sheep; Dog; Porcine; Rabbit; Guinea Porcine; Chicken
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b
Clone Number
CBP1572
Applications
IHC-P; IHC-Fr; WB; RIA
Application Notes
IHC-P (1/25-1/100)
Relevant Diseases
Alexander's Disease
Research Areas
Growth and Development
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1361
Product Properties
Form
Liquid
Formulation
PBS
0.09% Sodium Azide
0.09% Sodium Azide
Purification
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Target
References
1. Pegram, C.N. et al. (1985) Monoclonal antibodies reactive with epitopes restricted to glial fibrillary acidic proteins of several species.
2. McLendon, R.E. et al. (1986) The immunohistochemical application of three anti-GFAP monoclonal antibodies to formalin-fixed, paraffin-embedded, normal and neoplastic brain tissues.
2. McLendon, R.E. et al. (1986) The immunohistochemical application of three anti-GFAP monoclonal antibodies to formalin-fixed, paraffin-embedded, normal and neoplastic brain tissues.
Publications
Publications (0)
Neural Antibodies
Kits
Neural Genes
For Research Use Only. Not For Clinical Use.
