Mouse Anti-S100A8 Monoclonal Antibody (CBP6844)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Epitope

Binds to an located within the peptide sequence HAVYRDDLKKLLETE

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6844

Applications

IHC

Application Notes

IHC: 1:2000-1:5000

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

S100A8

Official Name

S100A8

Full Name

S100 Calcium Binding Protein A8

Alternative Names

S100 Calcium Binding Protein A8; Migration Inhibitory Factor-Related Protein 8; Leukocyte L1 Complex Light Chain; Urinary Stone Protein Band A; Calprotectin L1L Subunit; Cystic Fibrosis Antigen; MRP8; CAGA; CFAG; P8; S100 Calcium-Binding Protein A8 (Calgranulin A); S100 Calcium Binding Protein A8 (Calgranulin A); S100 Calcium-Binding Protein A8

Gene ID

6279(Human); 20201(Mouse)

Uniprot ID

P05109(Human); P27005(Mouse)