Mouse Anti-RGMA Monoclonal Antibody (CBP6848)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. Rejection guide molecule A (RGMa) is a bone morphogenetic protein (BMP) co-receptor of the rejection guide molecule family. It binds to BMPR1A and BMPR1B and ACVR2A and BMPR2, thereby binding BMP, thereby activating the intracellular SMAD1/5/8 signaling pathway. In humans, this protein is encoded by the RGMA gene. RGMa is a repelling guide molecule for retinal axons. In addition, neoflavomycin can be used as a receptor for RGM. The overexpression of Neogenin and the down-expression of RGM in the developing embryonic neural tube can induce apoptosis. The apoptotic activity of newborn neurons in the neural tube is related to the cleavage of its cytoplasmic domain by caspase. RGM can play an inhibitory role in prostate cancer by inhibiting cell growth, adhesion, migration and invasion. RGM can coordinate Smad-dependent and Smad-dependent signaling of BMP in prostate cancer and breast cancer cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6848

Applications

WB

Application Notes

WB: 1 µg/ml

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

RGMA

Official Name

RGMA

Full Name

Repulsive Guidance Molecule A

Alternative Names

RGMA; RGM; repulsive guidance molecule family member a; repulsive guidance molecule BMP co-receptor a

Gene ID

56963(Human); 244058(Mouse)

Uniprot ID

Q96B86(Human); Q6PCX7(Mouse); D4A188(Rat)