NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P617)

Product Overview

Description

The antibody has a high affinity for aggregated forms of α-synuclein and a low affinity for monomeric forms of α-synuclein. The antibody is useful in the diagnosis of neurodegenerative diseases.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

DB; ELISA; FC; IHC; In Vitro

Relevant Diseases

Parkinson's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

AlphaSynuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha

Gene ID

6622 (Human); 20617 (Mouse)

Uniprot ID

P37840

Product Pictures

ELISA

Figure 1 shows the results of inhibition ELISA using this antibody.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

Figure 2 shows the Pepscan results of a dot blot epitope assay for the monoclonal antibodies Syn-F1, Syn-F2, Syn-O1, Syn-O2, Syn-O3 and Syn-O4, and the Syn-1 antibody as a control.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

ELISA

Figure 3 shows the results of a sandwich ELISA for the detection of phosphorylated Ser129-α-synuclein aggregates.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

IHC

Figure 4 shows the immunohistochemical analysis of Parkinson's disease tissue.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

Publications