NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP2537)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

DB; ELISA; FC; IHC; In Vitro

Relevant Diseases

Parkinson's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

AlphaSynuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha

Product Pictures

ELISA

Fig.1 show the results of the inhibition ELISA using the antibody.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

Fig.2 shows the Pepscan results for the mAbs Syn-F1, Syn-F2, Syn-O1, Syn-O2, Syn-O3 and Syn-O4, and Syn-1 antibody (as a control) by dot blot for epitope determination.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

ELISA

Fig.3 show the results of the sandwich ELISA for the detection of phosphorylated Ser129-α-synuclein aggregates.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

IHC

Fig.4 shows the immunhistochemical analysis of tissues from Parkinson's disease.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

Publications