NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP2534)
[CAT#: NRZP-1022-ZP2534]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- DB; ELISA; FC; IHC; In Vitro
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
DB; ELISA; FC; IHC; In Vitro
Relevant Diseases
Parkinson's Disease
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
AlphaSynuclein
Official Name
SNCA
Full Name
Alpha-synuclein
Alternative Names
SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha
Product Pictures
ELISA
Fig.1 show the results of the inhibition ELISA using the antibody.
Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.
DB
Fig.2 shows the Pepscan results for the mAbs Syn-F1, Syn-F2, Syn-O1, Syn-O2, Syn-O3 and Syn-O4, and Syn-1 antibody (as a control) by dot blot for epitope determination.
Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.
ELISA
Fig.3 show the results of the sandwich ELISA for the detection of phosphorylated Ser129-α-synuclein aggregates.
Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.
IHC
Fig.4 shows the immunhistochemical analysis of tissues from Parkinson's disease.
Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.
FuncS
Fig.5 shows the % of puncta positive cells of each tested antibody.
Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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Cell Assay Reagents
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