NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP2539)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

WB; ELISA; IHC; In Vitro; In Vivo

Relevant Diseases

Parkinson's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

AlphaSynuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha

Product Pictures

ELISA

Fig.1 Recombinant human α-synuclein antibodies are directed against distinct epitopes.

Recombinant full-length and truncated α-synuclein was coated onto ELISA plates at equal coating concentration (20 μg/ml).

ELISA

Fig.2 Recombinant human α-synuclein antibodies bind α-synuclein but not β- and γ-synuclein in a direct ELISA.

Recombinant α-, β- and γ-synuclein coated onto ELISA plates at equal coating concentration (2 μg/ml) were incubated with recombinant human α-synuclein antibodies or with a pan synuclein antibody.

Publications