NeuroMab™ Anti-Amyloid Beta 1-15 Antibody(NRP-0422-P643)
[CAT#: NRP-0422-P643]
A functional antibody raised against Human, Cynomolgus Monkey β-amyloid.
- Host Species:
- Humanized
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- ELISA; FC; IHC; In Vitro; In Vivo
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The antibody is effective in disappearing Aβ plaques and can be used in or for the treatment, prevention or diagnosis of amyloidogenic diseases.
Species Reactivity
Human; Cynomolgus Monkey
Clonality
Monoclonal
Host Species
Humanized
Applications
ELISA; FC; IHC; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
>95% by SDS PAGE or HPLC
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Product Pictures
ELISA
Figure 1 is a graph depicting the binding of Aβ to chimeric 3D6 (PK1614) compared to mouse 3D6.
The sAPPβ/sAPPα ratio changes over time.
ELISA
Figure 2 is a graph depicting the competition of biotinylated 3D6 with unlabeled 3D6, PK1614 and 10D5 for Aβ binding.
The sAPPβ/sAPPα ratio changes over time.
ELISA
Figure 3 depicts the results of an ELISA measuring the binding of humanized 3D6v1 and chimeric 3D6 to aggregated Aβ.
The sAPPβ/sAPPα ratio changes over time.
IHC
Figure 4 Immunohistochemistry of PDAPP brain sections showing the specificity of the h3D6v1 antibody.
The sAPPβ/sAPPα ratio changes over time.
ELISA
Figure 5 Competitive binding assay of h3D6.
The sAPPβ/sAPPα ratio changes over time.
FuncS
Figure 6 In vitro assay using h3D6v2 antibody. The ability of h3D6v2 to stimulate microglia was tested by an in vitro phagocytosis assay.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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