NeuroMab™ Anti-Amyloid Beta 1-15 Antibody(NRP-0422-P643)
A functional antibody raised against Human, Cynomolgus Monkey β-amyloid.
- Host Species:
- Humanized
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- ELISA; FC; IHC; In Vitro; In Vivo
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
Species Reactivity
Clonality
Host Species
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 is a graph depicting the binding of Aβ to chimeric 3D6 (PK1614) compared to mouse 3D6.
The sAPPβ/sAPPα ratio changes over time.
Figure 2 is a graph depicting the competition of biotinylated 3D6 with unlabeled 3D6, PK1614 and 10D5 for Aβ binding.
The sAPPβ/sAPPα ratio changes over time.
Figure 3 depicts the results of an ELISA measuring the binding of humanized 3D6v1 and chimeric 3D6 to aggregated Aβ.
The sAPPβ/sAPPα ratio changes over time.
Figure 4 Immunohistochemistry of PDAPP brain sections showing the specificity of the h3D6v1 antibody.
The sAPPβ/sAPPα ratio changes over time.
Figure 5 Competitive binding assay of h3D6.
The sAPPβ/sAPPα ratio changes over time.
Figure 6 In vitro assay using h3D6v2 antibody. The ability of h3D6v2 to stimulate microglia was tested by an in vitro phagocytosis assay.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.
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