NeuroMab™ Anti-Kv3.1b potassium channel BBB Shuttle Antibody, Clone N16b/8

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNC1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number NP_036988)
Mouse: 100% identity (149/149 amino acids identical)
Human: 100% identity (84/84 amino acids identical, partial sequence)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N16B/8

Applications

WB; IHC; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNC1

Official Name

KCNC1

Full Name

Kv3.1b K+ channel

Alternative Names

Potassium Voltage-Gated Channel Subfamily C Member 1; Potassium Channel; Voltage Gated Shaw Related Subfamily C; Member 1; Voltage-Gated Potassium Channel Subunit Kv4; NGK2; Potassium Voltage-Gated Channel; Shaw-Related Subfamily; Member 1; Voltage-Gated Potassium Channel Protein KV3.1;

Uniprot ID

NP_036988

Product Pictures

Fig. 1 Immunoblot versus adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MBM) from Kv3.1/Kv3.3 double knockout and WT mice.

Fig. 2 Adult rat membrane immunoblot.

IHC

Fig. 3 Adult rat hippocampus immunohistochemistry.

Fig. 4 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Publications