NeuroMab™ Anti-Nav1.8 sodium channel BBB Shuttle Antibody, Clone N134/12

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN10A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8 (also known as Sodium channel protein type 10 or X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, Peripheral nerve sodium channel 3, PN3 or Sensory neuron sodium channel, accession number Q62968)
Mouse: 93% identity (220/235 amino acids identical)
Human: 85% identity (200/234 amino acids identical)
>50% identity with Nav1.7 and Nav1.5

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N134/12

Applications

WB; IHC; ICC

Application Notes

Does not react with Nav1.7

Research Areas

Na+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SCN10A

Official Name

SCN10A

Full Name

Nav1.8 Na+ channel

Alternative Names

hPN3; Nav1.8; PN3; SCN10A; SNS

Uniprot ID

Q62968

Product Pictures

Fig. 1 Stable/transfected cell immunoblot: extracts of HEK cells stably expressing Nav1.7 and COS cells transiently transfected with GFP-tagged Nav1.8 or untagged Kv2.1 plasmids and probed with N134/12 TC supe.