Product
NeuroMab™ Anti-Nav1.8 sodium channel BBB Shuttle Antibody, Clone N134/12
[CAT#: NRZP-0423-ZP284]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN10A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8 (also known as Sodium channel protein type 10 or X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, Peripheral nerve sodium channel 3, PN3 or Sensory neuron sodium channel, accession number Q62968)
Mouse: 93% identity (220/235 amino acids identical)
Human: 85% identity (200/234 amino acids identical)
>50% identity with Nav1.7 and Nav1.5
Mouse: 93% identity (220/235 amino acids identical)
Human: 85% identity (200/234 amino acids identical)
>50% identity with Nav1.7 and Nav1.5
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N134/12
Applications
WB; IHC; ICC
Application Notes
Does not react with Nav1.7
Research Areas
Na+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
SCN10A
Official Name
SCN10A
Full Name
Nav1.8 Na+ channel
Alternative Names
hPN3; Nav1.8; PN3; SCN10A; SNS
Uniprot ID
Q62968
Product Pictures
IB
Fig. 1 Stable/transfected cell immunoblot: extracts of HEK cells stably expressing Nav1.7 and COS cells transiently transfected with GFP-tagged Nav1.8 or untagged Kv2.1 plasmids and probed with N134/12 TC supe.
IF
Fig. 2 Immunofluorescence staining of cultured dorsal root ganglia neurons from Nav1.8 WT and KO mice with N134/12 TC supe.
IF
Fig. 3 Immunofluorescence staining of rat dorsal root ganglia cryosections. N134/12 TC supe=green, neurofilament=red.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
