NeuroMab™ Anti-Neuroligin-1 BBB Shuttle Antibody, Clone N97A/31

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Neuroligin 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 718-843 (cytoplasmic C-terminus) of rat Neuroligin-1 (also known as Nlgn1 and Kiaa1070, accession number Q62765)
Mouse: 99% identity (125/126 amino acids identical)
Human: 99% identity (125/126 amino acids identical)
>40% identity with Neuroligin-2 and -3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N97A/31

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with other Neuroligins

Research Areas

CAMs

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Neuroligin 1

Official Name

NLGN1

Full Name

Neuroligin-1

Alternative Names

NLGN1; NL1; neuroligin 1

Uniprot ID

Q62765

Product Pictures

Fig. 1 Immunoblot against crude membranes from adult mouse brain (MBM), extracts of COS cells transiently transfected with Neuroligin-1, -2, -3, -4 or -4* plasmid and extracts of brains from wild-type (WT) and Neuroligin-1 knockout (KO) mice probed with N97A/31 TC supe.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N97A/31 (left) or N52A/42 (right) TC supe.