Product
NeuroMab™ Anti-PSD-93/Chapsyn-110 scaffold protein BBB Shuttle Antibody, Clone N18/30
[CAT#: NRZP-0423-ZP353]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PSD 93 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-852 (full-length) of rat Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2, Dlg2 and Dlgh2, accession number Q63622)
Mouse: 99% identity (846/852 amino acids identical)
Human: 94% identity (826/870 amino acids identical)
>60% identity with other MAGUK family members (SAP97/Dlg1, SAP102/Dlg3 and PSD-95/Dlg4)
Mouse: 99% identity (846/852 amino acids identical)
Human: 94% identity (826/870 amino acids identical)
>60% identity with other MAGUK family members (SAP97/Dlg1, SAP102/Dlg3 and PSD-95/Dlg4)
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N18/30
Applications
WB; IHC; IP; ICC
Application Notes
Does not cross-react with SAP-97, SAP102 or PSD-95
Research Areas
Scaffolds
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
PSD 93
Official Name
DLG2
Full Name
PSD-93/Chapsyn-110
Alternative Names
DLG2; PPP1R58; PSD-93; PSD93; chapsyn-110; discs large homolog 2; discs large MAGUK scaffold protein 2
Uniprot ID
Q63622
Product Pictures
IB
Fig. 1 Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] probed with N18/30 (left) or N52A/42 (right) TC supe.
IB
Fig. 2 Immunoblot against crude membranes from whole adult rat brain (RBM) or hippocampi (MHM) from adult PSD-93/Chapsyn-110 knockout (KO) or wild-type (WT) mice.
IF
Fig. 3 Immunofluorescence staining of cultured rat hippocampal neurons with N18/30 (red), K13/31 (Kv1.4, green) and rabbit antiMAP2 (blue).
IHC
Fig. 4 Adult rat brain hippocampus immunohistochemistry.
IHC
Fig. 5 Adult rat cerebellumimmunohistochemistry.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
