NeuroMab™ Anti-PSD-93/Chapsyn-110 scaffold protein BBB Shuttle Antibody, Clone N18/28

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PSD 93 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-852 (full-length) of rat Chapsyn-110 (also known as Channelassociated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2, Dlg2 and Dlgh2, accession number Q63622)
Mouse: 99% identity (846/852 amino acids identical)
Human: 94% identity (826/870 amino acids identical)
>60% identity with other MAGUK family members (SAP97/Dlg1, SAP102/Dlg3 and PSD-95/Dlg4)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N18/28

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with SAP97, SAP102 or PSD-95

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PSD 93

Official Name

DLG2

Full Name

PSD-93/Chapsyn-110

Alternative Names

DLG2; PPP1R58; PSD-93; PSD93; chapsyn-110; discs large homolog 2; discs large MAGUK scaffold protein 2

Uniprot ID

Q63622

Product Pictures

Fig. 1 Immunofluorescence staining of 14 DIV cultured rat hippocampal neurons.

Fig. 2 Immunoblot against crude membrane preparations from adult rat brain (RBM) or hippocampi from adult wild-type (WT) or PSD93/Chapsyn-110 knockout (KO) mice probed with N18/28 (left) or K28/86 (right) TC supe.

Fig. 3 Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N18/28 (left) or N52A/42 (right) TC supe.