NeuroMab™ Anti-REEP2 BBB Shuttle Antibody, Clone N326D/2

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-REEP2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 111-254 (cytoplasmic C-terminus) of mouse REEP2 (also known as Receptor expression-enhancing protein 2, C5orf19, SGC32445 and LOC682105, accession number Q8VCD6)
Rat: 97% identity (140/144 amino acids identical)
Human: 86% identity (125/144 amino acids identical)
<40% identity with REEP1 and REEP4 but>65% identity for first 46 amino acids (RDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDL)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N326D/2

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with REEP1

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

REEP2

Official Name

REEP2

Full Name

REEP2

Alternative Names

Receptor Accessory Protein 2; SGC32445; C5orf19; Receptor Expression-Enhancing Protein 2; Chromosome 5 Open Reading Frame 19; SPG72; Yip2d;

Uniprot ID

Q8VCD6

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with Flagtagged REEP1, REEP2, REEP6 or untagged Kv2.1 plasmid probed with N326D/2 TC supe (left) or mouse anti-Flag (right).

Fig. 2 Immunofluorescence staining of adult rat cerebellum with N29/29 (green, synapses), N326D/2 (red, Purkinje cells) and Hoechst stain (blue, nuclei).