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Creative Biolabs
Product

NeuroMab™ Mouse Anti-NEFL Monoclonal Antibody (CBP1604)

[CAT#: NAB2007FY131]

Mouse Monoclonal [3G2] to NEFL

Host Species:
Mouse
Species Reactivity:
Human; Mouse
Applications:
WB

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Product Overview

Description

Mouse anti-human neurofilament antibody can recognize neurofilament, also known as light molecular weight neurofilament protein, neurofilament light polypeptide, neurofilament protein, light chain, neurofilament subunit NF-L, neurofilament triad L protein, neurofilament, Light polypeptide 68kDa and protein phosphatase 1 regulatory subunit 110. Neurofilament is a type IV intermediate filament heteropolymer composed of light chain, medium chain and heavy chain. Neurofilaments include an axoskeleton and functionally maintain the caliber of neurons. They may also play a role in intracellular transport to axons and dendrites. The NEFL gene encodes light chain neurofilament protein. Mutations in NEFL can cause Charcot-Marie-Tooth disease type 1F (CMT1F) and type 2E (CMT2E), which are diseases of the peripheral nervous system characterized by obvious neuropathy.

Immunogen

Recombinant protein fragment corresponding to amino acids 1-360 of human neurofilament (NP_006149) produced in E. coli.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1604

Applications

WB

Application Notes

WB (1/1000)

Research Areas

Growth and Development

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1379
Product Properties

Form

Liquid

Formulation

PBS
0.09% Sodium Azide
1% BSA
50% Glycerol

Purification

Mouse monoclonal antibody purified by affinity chromatography from ascites.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Target

Target

Neurofilament L

Official Name

NEFL

Full Name

Neurofilament light polypeptide

Alternative Names

NEFL; CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110; neurofilament; light polypeptide; neurofilament light; CMTDIG

Gene ID

4747 (Human); 18039 (Mouse); 83613 (Rat)

Uniprot ID

P07196 (Human); P08551 (Mouse); P19527 (Rat)
Publications

Publications (0)

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