Product
NeuroMab™ Mouse Anti-ANK1 Monoclonal Antibody (CBP2365)
[CAT#: NAB2010369LS]
Anti-ANK1 Monoclonal Antibody [HRP]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Ankyrin-R is an anchor protein whose main role in vivo is to anchor integral membrane protein/complexes to the cytoskeleton. It was originally discovered in erythrocytes, but later to be found expressed in the brain. The gene encoding Ankyrin-R, ANK1, has a highly complex regulatory mechanism, which gives rise to a variety of different isoforms of Ankyrin-R. Recent studies in Alzheimer's Disease have shown that epigenetic dysregulation of ANK1, in combination of several other proteins including Trem-2, could be a contributing factor of increased TNFA expression and neuroinflammation1.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
CBP2365
Applications
WB
Application Notes
WB (2-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1746
Product Properties
Form
Liquid
Formulation
This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
ANK1
Official Name
ANK1
Full Name
Ankyrin-1
Alternative Names
ANK1; Ankyrin-R
References
1. Morris G, et al. 2018. Mol Neurobiol. doi: 10.1007/s12035-018-1092-y.
2. Nicolas V, et al. 2006. Transfuse Clin Biol. 13(1-2):23
3. Kline CF, et al. 2006. Expert Rev Cardiovasc Ther. 4(4):477
2. Nicolas V, et al. 2006. Transfuse Clin Biol. 13(1-2):23
3. Kline CF, et al. 2006. Expert Rev Cardiovasc Ther. 4(4):477
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
